Bernthal Nicholas M, Upfill-Brown Alexander, Burke Zachary D C, Greig Danielle, Hwang Richard, Crawford Brooke, Eckardt Jeffrey J
Department of Orthopaedic Surgery, University of California Los Angeles, Los Angeles, California.
J Surg Oncol. 2020 Sep;122(4):778-786. doi: 10.1002/jso.26080. Epub 2020 Jun 29.
There is a paucity of data on long-term survivorship and outcomes for total humerus replacements (THR) with only two series reporting 10-year survival.
A review of 769 consecutive, prospectively collected endoprosthetic reconstructions for oncological diagnoses at a single-center between 1980 and 2019 was performed. Patients with THRs were isolated and analyzed for outcomes, complications, and modes of failure.
Eighteen patients with 20 THR implants were identified. The median follow-up for surviving patients was 148 months (interquartile range [IQR] = 74-194) and 60 months (IQR = 17-155 months) for all patients. Two prostheses required revision for failure, both for symptomatic shoulder dislocation. There were three local recurrences. Revision-free survival at 5, 10, and 15 years was 100%, 86% and 86%, respectively. There were no cases of ulnar component failure, radial nerve palsy, or periprosthetic infection.
THR prosthesis survivorship is comparable to the previous series, with a longer follow-up than has previously been reported. Symptomatic shoulder instability was common (25%), and was the only cause of revision. Reverse total shoulder could be an important way to address this in the future. Local recurrence rates were high, as has been reported elsewhere for THR.
关于全肱骨置换术(THR)的长期生存率和预后的数据匮乏,仅有两个系列报道了10年生存率。
对1980年至2019年期间在单中心前瞻性收集的769例连续的肿瘤诊断的假体置换重建病例进行了回顾。分离出接受全肱骨置换术的患者,并分析其预后、并发症及失败模式。
共确定了18例患者的20个全肱骨置换植入物。存活患者的中位随访时间为148个月(四分位间距[IQR]=74 - 194),所有患者的中位随访时间为60个月(IQR = 17 - 155个月)。两个假体因失败需要翻修,均为有症状的肩关节脱位。有3例局部复发。5年、10年和15年的无翻修生存率分别为100%、86%和86%。没有尺骨部件失败、桡神经麻痹或假体周围感染的病例。
全肱骨置换假体的生存率与先前系列相当,随访时间比先前报道的更长。有症状的肩关节不稳定很常见(25%),并且是翻修的唯一原因。反向全肩关节置换术可能是未来解决这一问题的重要方法。局部复发率较高,正如其他地方报道的全肱骨置换术情况一样。