Franceschi S, Tirelli U, Vaccher E, Serraino D, Crovatto M, De Paoli P, Diodato S, La Vecchia C, Decarli A, Monfardini S
Regional Center for Oncological Referral, Aviano, Italy.
Int J Epidemiol. 1988 Mar;17(1):162-7. doi: 10.1093/ije/17.1.162.
Prevalence and determinants of HIV infection were assessed in 313 parenteral drug addicts admitted to five Centers for Drug-Addict Assistance and two prisons located in the northeast of Italy (Friuli Venezia-Giulia), an area some distance from the major Italian cities first reached by the AIDS epidemic. The overall prevalence of HIV positivity was also rather high in this area, ie 30% with 24-36% confidence interval. The most important risk factors (besides syringe sharing applicable to all drug addicts), turned out to be of a geographical nature, ie living in Pordenone province (where a US military base is located) or coming from other endemic areas and having travelled long distances in the past three years. Prostitution also seemed to increase the risk of infection, but duration of drug addiction had little effect. In addition to persistent generalized lymphadenopathy (closely linked to HIV infection), reversal of helper:suppressor T-cell ratio was found in 67% of HIV positive individuals, but also in 31% of HIV negative ones. Clinical signs and symptoms strongly linked with HIV positivity were fatigue, weight loss, splenomegaly, fever and nocturnal sweats.
在意大利东北部（弗留利-威尼斯朱利亚）的五个戒毒援助中心和两所监狱收治的313名注射吸毒者中，评估了艾滋病毒感染的患病率及其决定因素。该地区距离意大利首先出现艾滋病疫情的主要城市有一段距离。该地区艾滋病毒阳性的总体患病率也相当高，即30%，置信区间为24%-36%。最重要的风险因素（除了适用于所有吸毒者的共用注射器之外），结果显示具有地理性质，即居住在波代诺内省（那里有一个美国军事基地）或来自其他疫区并且在过去三年中长途旅行过。卖淫似乎也增加了感染风险，但吸毒成瘾的持续时间影响不大。除了持续性全身性淋巴结肿大（与艾滋病毒感染密切相关）之外，在67%的艾滋病毒阳性个体中发现了辅助性T细胞与抑制性T细胞比例的倒置，但在31%的艾滋病毒阴性个体中也有发现。与艾滋病毒阳性密切相关的临床体征和症状有疲劳、体重减轻、脾肿大、发热和盗汗。
