Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.
Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium.
Acta Ophthalmol. 2021 Feb;99(1):16-25. doi: 10.1111/aos.14508. Epub 2020 Jun 29.
Insights in the ocular surface microbiome are still at an early stage and many more questions remain unanswered compared with other human-associated microbial communities. The current knowledge on the human microbiome changed our viewpoint on bacteria and human health and significantly enhanced our understanding of human pathophysiology. Also in ocular medicine, microbiome research might impact treatment. Here, we summarize the current knowledge on ocular microbiome research with a particular focus on potential confounding factors and their effects on microbiome composition. Moreover, we present the ocular surface core microbiome based on current available data and defined it as genera present in almost half of the published control cohorts with a relative abundance of at least 1%.
关于眼表面微生物组的研究仍处于早期阶段，与其他与人体相关的微生物群落相比，还有许多问题尚未得到解答。目前对人类微生物组的了解改变了我们对细菌和人类健康的看法，并极大地增强了我们对人类病理生理学的理解。在眼科学领域，微生物组研究也可能影响治疗方法。在这里，我们总结了目前关于眼微生物组研究的知识，特别关注了潜在的混杂因素及其对微生物组组成的影响。此外，我们根据目前已有的数据提出了眼表面核心微生物组的概念，并将其定义为存在于近一半已发表对照队列中的属，其相对丰度至少为 1%。
