NSC "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv, Kyiv 01033,Ukraine.
RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NASU, Kyiv 03022, Ukraine.
Exp Oncol. 2020 Jun;42(2):82-93. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-2.14611.
This review presents up-to-date information on the effects of microbiota on the individual chemotherapy sensitivity in cancer treatment. Recent studies have shown that a fine balance between the intestinal microbiota and the immune system is crucial for maintaining an efficacy of cancer chemotherapy. A number of antitumor drugs have complex mechanisms of action involving not only direct effects but also the activity of the intestinal microbiota and the immune system. A unique combination of these factors contributes to the individual chemotherapy sensitivity.
这篇综述介绍了关于肠道微生物群对癌症治疗中个体化疗敏感性影响的最新信息。最近的研究表明，肠道微生物群和免疫系统之间的微妙平衡对于维持癌症化疗的疗效至关重要。许多抗肿瘤药物的作用机制复杂，不仅涉及直接作用，还涉及肠道微生物群和免疫系统的活性。这些因素的独特组合导致了个体化疗敏感性的差异。
