Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90025.
Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90025.
Tex Heart Inst J. 2020 Apr 1;47(2):163-164. doi: 10.14503/THIJ-18-6872.
Acquired long QT syndrome is typically caused by medications, electrolyte disturbances, bradycardia, or catastrophic central nervous system events. We report a case of myocardial infarction-related acquired long QT syndrome in a 58-year-old woman that had no clear cause and progressed to torsades de pointes requiring treatment with isoproterenol and magnesium. Despite negative results of DNA testing against a known panel of genetic mutations and polymorphisms associated with long QT syndrome, the patient's family history of fatal cardiac disease suggests a predisposing genetic component. This report serves to remind clinicians of this potentially fatal ventricular arrhythmia after myocardial infarction.
获得性长 QT 综合征通常由药物、电解质紊乱、心动过缓或灾难性中枢神经系统事件引起。我们报告了一例 58 岁女性与心肌梗死相关的获得性长 QT 综合征,其病因不明确,进展为尖端扭转型室性心动过速,需要异丙肾上腺素和镁治疗。尽管针对与长 QT 综合征相关的已知基因突变和多态性基因检测呈阴性,但该患者家族中存在致命性心脏病病史,提示存在易患遗传因素。本报告旨在提醒临床医生注意心肌梗死后发生这种潜在致命性室性心律失常的可能性。