Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Environ Int. 2020 Sep;142:105903. doi: 10.1016/j.envint.2020.105903. Epub 2020 Jun 27.
Dyslipidemia is a major risk factor for cardiovascular disease. Several studies have explored the associations of greenness with blood lipids. However, the evidence is still limited and mixed, especially in rural areas.
From May to September 2016, we recruited 4735 Uyghur adults from rural areas of northwestern China. We measured levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Two satellite-derived vegetation indices - Normalized Difference Vegetation Index (NDVI) and Soil Adjusted Vegetation Index (SAVI) - were used to estimate residential greenness levels. The associations between exposure to residential greenness and blood lipids levels and dyslipidemia prevalence were examined using the Generalized Linear Mixed Models.
Living in greener areas was associated with lower TG levels, higher HDL-C levels, and lower odds of hypoalphalipoproteinemia (e.g., per 0.20-unit increase in NDVI was associated with 0.02 mmol/L (95% CI: 0.001, 0.03) higher levels of HDL-C and 0.87-fold (95% CI: 0.77, 0.98) lower odds of hypoalphalipoproteinemia). These associations remained in a series of sensitivity analyses. Stratified analyses showed that the associations of NDVI with LDL-C and HDL-C levels were stronger in women and in participants with higher education level.
Higher greenness exposure was beneficially associated with blood lipids among rural Uyghur population in China, especially among women or those with higher education level.
血脂异常是心血管疾病的一个主要危险因素。已有多项研究探讨了绿色环境与血脂之间的关联。然而，证据仍然有限且存在分歧，尤其是在农村地区。
2016 年 5 月至 9 月，我们从中国西北地区的农村地区招募了 4735 名维吾尔族成年人。我们测量了总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）的水平。使用两种卫星衍生的植被指数——归一化差异植被指数（NDVI）和土壤调整植被指数（SAVI）——来估计居住环境的绿化水平。使用广义线性混合模型来检验暴露于居住绿化环境与血脂水平和血脂异常患病率之间的关联。
生活在绿化程度较高的地区与较低的 TG 水平、较高的 HDL-C 水平和较低的低蛋白血症患病率相关（例如，NDVI 每增加 0.20 个单位，HDL-C 水平就会升高 0.02mmol/L（95%CI：0.001，0.03），低蛋白血症的患病风险降低 0.87 倍（95%CI：0.77，0.98））。这些关联在一系列敏感性分析中仍然存在。分层分析表明，NDVI 与 LDL-C 和 HDL-C 水平的关联在女性和受教育程度较高的参与者中更强。
较高的绿化暴露与中国农村维吾尔族人群的血脂水平呈有益关联，尤其是在女性或受教育程度较高的人群中。
