Crane Tracy E, Badger Terry A, Sikorskii Alla, Segrin Chris, Hsu Chiu-Hsieh, Rosenfeld Anne G
Tracy E. Crane, PhD, RDN, is Assistant Professor, University of Arizona, Tucson. Terry A. Badger, PhD, RN, PMHCNS-BC, FAAN, is Professor, University of Arizona, Tucson. Alla Sikorskii, PhD, is Professor, Michigan State University, East Lansing. Chris Segrin, PhD, is Professor, University of Arizona, Tucson. Chiu-Hsieh Hsu, PhD, is Professor, University of Arizona, Tucson. Anne G. Rosenfeld, PhD, RN, CNS, FAHA, FAAN, is Professor, University of Arizona, Tucson.
Nurs Res. 2020 Jul/Aug;69(4):264-271. doi: 10.1097/NNR.0000000000000434.
Symptom research among Latinas with breast cancer is limited-especially as it relates to multiple co-occurring symptoms.
The aim of the study was to identify subgroups (latent classes) of Latinas who have distinct symptom profiles while receiving radiation, chemotherapy, and/or hormonal therapy for breast cancer.
This secondary analysis included intake data from three randomized trials of supportive care psychosocial interventions for Latinas treated for breast cancer (n = 290). Prevalence of 12 symptoms-measured using the General Symptom Distress Scale-was entered into the latent class analysis to identify classes of women with different symptom profiles.
Most of the participants had Stage II or III disease, and 81% reported receiving chemotherapy. On average, women reported 4.2 (standard deviation [SD] = 3) symptoms with an overall symptom distress score of 6.4 (SD = 2.5) on a 1-10 scale, with 10 being most distressing. Latent class analysis resulted in three classes that were labeled based on symptoms with the highest prevalence. Class 1 (n = 192) was "Disrupted Sleep and Tired," Class 2 (n = 74) was "Tired," and Class 3 (n = 24) was "Pain, Disrupted Sleep, and Tired." Depression, anxiety, and difficulty concentrating had moderate prevalence in each of the three classes.
Beyond the core six symptoms (depression, anxiety, fatigue, pain, disrupted sleep, difficulty concentration), the classes differed in the prevalence of other burdensome symptoms (e.g., nausea, vomiting, constipation), which provide implications for treatment. Thus, it is important to assess for the full range of symptoms so that supportive care interventions can be tailored for the distinct symptom profiles of Latinas with breast cancer.
拉丁裔乳腺癌患者的症状研究有限，尤其是与多种并发症状相关的研究。
本研究旨在确定在接受乳腺癌放疗、化疗和/或激素治疗时具有不同症状特征的拉丁裔亚组（潜在类别）。
这项二次分析纳入了三项针对拉丁裔乳腺癌患者的支持性护理心理社会干预随机试验的入组数据（n = 290）。使用一般症状困扰量表测量的12种症状的患病率被纳入潜在类别分析，以确定具有不同症状特征的女性类别。
大多数参与者患有II期或III期疾病，81%的人报告接受了化疗。女性平均报告有4.2种症状（标准差[SD]=3），在1-10分的量表上，总体症状困扰评分为6.4（SD = 2.5），10分为最困扰。潜在类别分析产生了三个类别，根据患病率最高的症状进行标记。第1类（n = 192）为“睡眠中断和疲劳”，第2类（n = 74）为“疲劳”，第3类（n = 24）为“疼痛、睡眠中断和疲劳”。抑郁、焦虑和注意力不集中在这三个类别中患病率中等。
除了核心的六种症状（抑郁、焦虑、疲劳、疼痛、睡眠中断、注意力不集中）外，这些类别在其他负担性症状（如恶心、呕吐、便秘）的患病率上有所不同，这为治疗提供了启示。因此，全面评估症状很重要，以便能够针对拉丁裔乳腺癌患者的不同症状特征量身定制支持性护理干预措施。
