Division of Head & Neck Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, Sichuan Province, China.
Cancer Day-care Unit, Division of Medical Oncology, Cancer Center, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan Province, China.
PLoS One. 2024 Sep 18;19(9):e0308907. doi: 10.1371/journal.pone.0308907. eCollection 2024.
To analyze the relationship between experience of symptoms (e.g., pain, fatigue) and fear of cancer recurrence (FCR) in Chinese postoperative patients with breast cancer undergoing chemotherapy.
A total of 225 patients were recruited using convenience sampling. The Fear of Cancer Recurrence Inventory-Chinese Version and the Symptom Experience Index were used to collect data. The Mann-Whitney U test, Spearman's correlation, and multivariate analysis were employed to explore the relationships between symptom experience and FCR.
The total Fear of Cancer Recurrence Inventory score in postoperative patients with breast cancer undergoing chemotherapy was 43.19±22.83, and >64.0% of participants exhibited significant fear of cancer recurrence. The total score of symptom experience was 27.41±16.77, including scores of symptom severity (16.91±8.70) and symptom distress (10.50±8.89). Participants' symptom experience was positively correlated with fear of cancer recurrence (r = 0.353, P < 0.001). Patients with clinically relevant FCR had higher scores for total symptom experience (Z = -3.911, P<0.001), symptom severity (Z = -3.245, P = 0.001), and symptom distress (Z = -4.185, P<0.001), compared to patients without clinically relevant FCR. Symptom experience (b = 0.511, t = 6.474, P<0.001), age (b = -0.591, t = -4.201, P<0.001), and educational level (b = 4.147, t = 3.955, P<0.001) were statistically correlated with FCR, accounting for 27.0% of the variance. Among these variables, symptom experience demonstrated the strongest correlation, with a beta value of 0.371.
This study followed others in identifying a cross-sectional relationship between symptom experience and FCR. Further prospective research is required to better understand the nature of this relationship.
分析中国接受化疗的乳腺癌术后患者症状体验（如疼痛、疲劳）与癌症复发恐惧（FCR）之间的关系。
采用便利抽样法招募 225 名患者。使用癌症复发恐惧量表-中文版和症状体验指数收集数据。采用 Mann-Whitney U 检验、Spearman 相关分析和多元分析探讨症状体验与 FCR 之间的关系。
接受化疗的乳腺癌术后患者的 FCR 总分中位数为 43.19±22.83，>64.0%的患者表现出明显的癌症复发恐惧。症状体验总分中位数为 27.41±16.77，包括症状严重程度（16.91±8.70）和症状困扰（10.50±8.89）得分。患者的症状体验与癌症复发恐惧呈正相关（r=0.353，P<0.001）。有临床相关 FCR 的患者的总症状体验（Z=-3.911，P<0.001）、症状严重程度（Z=-3.245，P=0.001）和症状困扰（Z=-4.185，P<0.001）得分均高于无临床相关 FCR 的患者。症状体验（b=0.511，t=6.474，P<0.001）、年龄（b=-0.591，t=-4.201，P<0.001）和教育水平（b=4.147，t=3.955，P<0.001）与 FCR 呈统计学相关，共解释了 27.0%的方差。在这些变量中，症状体验与 FCR 的相关性最强，β值为 0.371。
本研究与其他研究一样，发现症状体验与 FCR 之间存在横断面关系。需要进一步的前瞻性研究来更好地理解这种关系的本质。
