Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, WA, USA.
S. B. Cook, Surgical Outcomes Research Center, Department of Surgery, University of Washington, Seattle, WA, USA.
Clin Orthop Relat Res. 2020 Oct;478(10):2266-2273. doi: 10.1097/CORR.0000000000001370.
Patients with femoroacetabular impingement (FAI) may experience lasting clinical improvement after hip arthroscopy; however, some patients will still eventually undergo early conversion to THA due to unresolved symptoms and progression of arthritis. However, the risk of this has been only incompletely characterized in prior studies.
QUESTIONS/PURPOSES: Using a large healthcare claims database over a 5-year period (2011-2016), we asked: (1) What is the survivorship free from THA after arthroscopic osteoplasty performed for FAI? (2) What identifiable demographic factors and patient characteristics are associated with early conversion to THA after hip arthroscopy performed for FAI?
We included all patients who underwent hip arthroscopy for FAI, between the ages of 12 years and 63 years, with 3 months of claims data before hip arthroscopy and minimum 2-year follow-up. A total of 4730 hip arthroscopy patients from 2011 to 2014 were retrieved from a US commercial claims database. Hip arthroscopy incidence doubled over time from 1.2 to 2.1 persons per 100,000. Temporal trends, patient demographics, diagnoses at time of arthroscopy, and patient comorbidities were retrieved and logistic regression performed. Survivorship analysis on 11,323 patients (lifting the 2-year follow-up requirement) was also performed to identify independent variables associated with early risk of conversion to THA.
In patients undergoing hip arthroscopy for FAI, the overall proportion of conversion to THA within 2 years after hip arthroscopy was 7% (338 of 4730). After controlling for confounding variables such as sex, obesity, and depression, we found the following were independently associated with increased odds of conversion to THA: older age (odds ratio 1.08 [95% CI 1.01 to 1.10]; p < 0.001), osteoarthritis (OR 2.91 [95% CI 2.27 to 3.77]; p < 0.001), joint inflammation (OR 1.89 [95% CI 1.16 to 3.09]; p = 0.01), and a history of opioid use (OR 2.17 [95% CI 1.69 to 2.79]; p < 0.001). Survivorship analysis similarly revealed that older age (hazard ratio 1.08 [95% CI 1.07 to 1.09]; p < 0.001), osteoarthritis (HR 2.53 [95% CI 2.13 to 3.01]; p < 0.001), joint inflammation (HR 1.53 [95% CI 1.10 to 2.11]; p = 0.01), a history of opioid use (HR 2.02 [95% CI 1.71 to 2.38]; p < 0.001), and smoking (HR 1.55 [95% CI 1.14 to 2.11]; p = 0.005), were independently associated with increased odds of conversion to THA within 2 years after hip arthroscopy for FAI.
Although the findings of this study are limited and should not be taken in isolation, patients with FAI who are older, carry diagnoses of inflammatory or degenerative articular disease, or who use opioids or smoke should be counseled about a potentially increased risk of undergoing early conversion to THA after hip arthroscopy. Future studies to further examine the effect of these diagnoses in prospectively collected cohorts, incorporating radiographic and patient-reported outcome measures, are needed.
Level III, prognostic study.
患有股骨髋臼撞击症(FAI)的患者在髋关节镜手术后可能会持续出现临床改善;然而,由于症状未得到解决和关节炎的进展,一些患者最终仍会早期转为全髋关节置换术(THA)。然而,在之前的研究中,这种风险仅被不完全描述。
问题/目的:使用 5 年期间(2011-2016 年)的大型医疗保健索赔数据库,我们提出以下问题:(1)对于因 FAI 行髋关节镜下骨成形术的患者,无 THA 生存的情况如何?(2)哪些可识别的人口统计学因素和患者特征与因 FAI 行髋关节镜手术后早期转为 THA 相关?
我们纳入了所有在 12 岁至 63 岁之间因 FAI 行髋关节镜手术的患者,在髋关节镜手术前有 3 个月的索赔数据,并进行了至少 2 年的随访。从美国商业索赔数据库中检索到 2011 年至 2014 年的 4730 例髋关节镜手术患者。髋关节镜手术的发生率从每 100,000 人 1.2 人增加到 2.1 人,时间翻倍。检索了患者人口统计学、手术时的诊断和患者合并症等时间趋势、患者特征,并进行了逻辑回归。对 11323 例患者(解除了 2 年随访要求)进行生存分析,以确定与早期转为 THA 风险相关的独立变量。
在因 FAI 行髋关节镜手术的患者中,髋关节镜手术后 2 年内转为 THA 的总体比例为 7%(4730 例中的 338 例)。在控制性别、肥胖和抑郁等混杂变量后,我们发现以下因素与转为 THA 的几率增加独立相关:年龄较大(优势比 1.08 [95%置信区间 1.01 至 1.10];p < 0.001)、骨关节炎(比值比 2.91 [95%置信区间 2.27 至 3.77];p < 0.001)、关节炎症(比值比 1.89 [95%置信区间 1.16 至 3.09];p = 0.01)和阿片类药物使用史(比值比 2.17 [95%置信区间 1.69 至 2.79];p < 0.001)。生存分析同样表明,年龄较大(风险比 1.08 [95%置信区间 1.07 至 1.09];p < 0.001)、骨关节炎(风险比 2.53 [95%置信区间 2.13 至 3.01];p < 0.001)、关节炎症(风险比 1.53 [95%置信区间 1.10 至 2.11];p = 0.01)、阿片类药物使用史(风险比 2.02 [95%置信区间 1.71 至 2.38];p < 0.001)和吸烟史(风险比 1.55 [95%置信区间 1.14 至 2.11];p = 0.005)与髋关节镜手术后 2 年内转为 THA 的几率增加独立相关。
尽管这些研究结果是有限的,不应该孤立地看待,但对于患有 FAI 的患者,如果年龄较大、患有炎症或退行性关节疾病的诊断,或使用阿片类药物或吸烟的患者,应告知他们在髋关节镜手术后早期转为 THA 的风险可能会增加。需要进一步研究这些诊断在前瞻性收集的队列中的作用,包括影像学和患者报告的结果测量。
三级,预后研究。