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髋关节镜治疗症状性股骨髋臼撞击症与非手术治疗患者的长期随访中骨关节炎的进展。

Progression of Osteoarthritis at Long-term Follow-up in Patients Treated for Symptomatic Femoroacetabular Impingement With Hip Arthroscopy Compared With Nonsurgically Treated Patients.

机构信息

Department of Orthopedic Surgery and Sports Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Department of Orthopaedic Surgery, University Hospital Heidelberg, Heidelberg, Germany.

出版信息

Am J Sports Med. 2023 Sep;51(11):2986-2995. doi: 10.1177/03635465231188114. Epub 2023 Aug 8.

DOI:10.1177/03635465231188114
PMID:37551688
Abstract

BACKGROUND

Femoroacetabular impingement (FAI) is a common cause of hip pain, especially in young patients. When left untreated, it has been demonstrated to be a risk factor for the onset or progression of osteoarthritis (OA) and has been identified as one of the main contributors leading to the need for total hip arthroplasty (THA) at a young age. While the short-term therapeutic potential of hip arthroscopy is widely recognized, little is known regarding its potential mid- to long-term preventive effect on the progression of hip OA.

PURPOSE

To (1) report clinical outcomes of arthroscopically treated FAI syndrome with a minimum 5-year follow-up and compare the results to a cohort with FAI treated nonsurgically and (2) determine the influence of hip arthroscopy on the onset and progression of hip OA in patients diagnosed with FAI.

STUDY DESIGN

Cohort study; Level of evidence, 3.

METHODS

Patients who had hip pain and were diagnosed with FAI were included. Exclusion criteria were (1) previous or concomitant hip surgery, (2) <5 years of follow-up, and (3) insufficient radiographs. Patients treated with hip arthroscopy were compared with a cohort of patients with FAI who were treated nonsurgically. Kaplan-Meier estimates of failure (defined as conversion to THA) were performed. Bivariate analysis and Cox regression were used to identify factors associated with inferior clinical and radiographic outcomes.

RESULTS

A total of 957 patients (650 female, 307 male; 1114 hips) (mean age, 28.03 ± 8.9 years [range, 6.5-41.0 years]) with FAI were included. A total of 132 hips underwent hip arthroscopy and 982 hips were nonoperatively treated. The mean follow-up was 12.5 ± 4.7 years (range, 5.0-23.4 years). At the final follow-up, the rate of OA progression was 26.5% in the operative group and 35.2% in the nonoperative cohort ( < .01). Conversion to THA was performed in 6.8% of the surgical patients and 10.5% of the initially nonsurgical patients ( = .19). Additionally, there was no significant difference in the risk of failure between the operatively and nonoperatively treated patients. Male sex, increased age at initial diagnosis, presence of cam morphology, and increased initial Tönnis grade were risk factors for failure (male sex: hazard ratio [HR], 2.3; < .01; per year of increased age: HR, 1.1; < .01; presence of cam: HR, 3.5; < .01; per Tönnis grade: HR, 4.0; < .01).

CONCLUSION

At a mean follow-up of nearly 13 years, 7% of patients of the surgical group experienced progression to THA, compared with 11% of the nonoperative control group. While most of the operative group showed little to no OA at final follow-up, moderate OA (Tönnis grade 2) was present in 12% of the cohort compared with 22% of nonsurgical patients. Increased age at diagnosis, male sex, presence of a cam morphology, and presence of initial arthritic joint changes were found to be risk factors for failure. The results of this study demonstrated evidence for a preventive effect of hip arthroscopy on the development and progression of OA in young patients with FAI at mid- to long-term follow-up.

摘要

背景

股骨髋臼撞击症(FAI)是髋关节疼痛的常见原因,尤其在年轻患者中更为常见。如果不进行治疗,它已被证明是髋关节骨关节炎(OA)发病或进展的危险因素之一,并已被确定为导致年轻患者需要全髋关节置换术(THA)的主要因素之一。虽然髋关节镜短期治疗的潜力已被广泛认可,但对于其在髋关节 OA 进展方面的潜在中期至长期预防作用知之甚少。

目的

(1)报告至少随访 5 年的关节镜治疗 FAI 综合征的临床结果,并与接受非手术治疗的 FAI 患者进行比较;(2)确定髋关节镜治疗对 FAI 患者髋关节 OA 发病和进展的影响。

研究设计

队列研究;证据等级,3 级。

方法

纳入髋关节疼痛且被诊断为 FAI 的患者。排除标准为:(1)既往或同时行髋关节手术;(2)随访时间<5 年;(3)影像学资料不充分。对接受髋关节镜治疗的患者与接受非手术治疗的 FAI 患者队列进行比较。采用 Kaplan-Meier 失败估计(定义为转换为 THA)。采用双变量分析和 Cox 回归分析确定与临床和影像学结果较差相关的因素。

结果

共纳入 957 例(650 例女性,307 例男性;1114 髋)(平均年龄 28.03 ± 8.9 岁[范围,6.5-41.0 岁])FAI 患者。132 髋接受髋关节镜治疗,982 髋接受非手术治疗。平均随访时间为 12.5 ± 4.7 年(范围,5.0-23.4 年)。在最终随访时,手术组的 OA 进展率为 26.5%,非手术组为 35.2%(<0.01)。手术患者中有 6.8%和非手术初始治疗患者中有 10.5%(=0.19)转为 THA。此外,手术和非手术治疗患者的失败风险无显著差异。男性、初诊年龄较大、存在凸轮形态和初始 Tönnis 分级增加是失败的危险因素(男性:风险比[HR],2.3;<0.01;每增加 1 岁:HR,1.1;<0.01;存在凸轮:HR,3.5;<0.01;每增加 1 个 Tönnis 分级:HR,4.0;<0.01)。

结论

在平均随访近 13 年时,手术组中有 7%的患者进展为 THA,而对照组中非手术组有 11%的患者进展为 THA。虽然大多数手术组在最终随访时几乎没有或没有 OA,但与非手术组患者的 22%相比,该队列中有 12%的患者存在中度 OA(Tönnis 分级 2)。诊断时年龄较大、男性、存在凸轮形态和存在初始关节炎改变是失败的危险因素。本研究结果表明,髋关节镜治疗在年轻 FAI 患者中具有预防 OA 发病和进展的中期至长期效果。

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