Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea .
Retina. 2021 Mar 1;41(3):630-637. doi: 10.1097/IAE.0000000000002872.
To investigate the clinical characteristics and prognostic factors of young patients with central retinal vein occlusion (CRVO).
This retrospective cohort study involved treatment-naïve patients with CRVO. Medical records regarding basic demographics, predisposing factors, ocular characteristics, and treatments were reviewed and compared according to age at CRVO onset.
We enrolled 263 patients, of whom 69 were younger patients. Younger patients had higher prevalence of nontraditional risk factors including physical or psychological stress (P = 0.032), hematologic abnormalities (P = 0.003), and better visual acuity at baseline and last visit (all P < 0.001) and were unlikely to undergo intravitreal injections (47.8 vs. 68.6%, P < 0.001) during follow-up. Younger patients had higher prevalence of paracentral acute middle maculopathy (28.1 vs. 4.7%, P < 0.001). Older age (odds ratio = 1.165, P = 0.028), male sex (odds ratio = 7.074, P = 0.034), coexisting renal disease (odds ratio = 7.845, P = 0.050), and poor baseline visual acuity (odds ratio = 16.069, P = 0.002) were significant risk factors for poor visual outcomes in young CRVO patients.
Younger CRVO patients had a milder clinical course with fewer treatments and were more likely to have nontraditional risk factors than older patients.
研究青年型中央视网膜静脉阻塞（CRVO）患者的临床特征和预后因素。
本回顾性队列研究纳入了未经治疗的 CRVO 患者。根据 CRVO 发病时的年龄，回顾并比较了病历中的基本人口统计学、诱发因素、眼部特征和治疗情况。
共纳入 263 例患者，其中 69 例为年轻患者。年轻患者非传统危险因素（包括身体或心理压力、血液学异常）的患病率更高（P = 0.032、P = 0.003），基线和最后一次就诊时视力更好（均 P < 0.001），随访期间不太可能接受玻璃体内注射（47.8% vs. 68.6%，P < 0.001）。年轻患者更易发生旁中心急性中重度黄斑病变（28.1% vs. 4.7%，P < 0.001）。年龄较大（比值比 = 1.165，P = 0.028）、男性（比值比 = 7.074，P = 0.034）、合并肾脏疾病（比值比 = 7.845，P = 0.050）和基线视力较差（比值比 = 16.069，P = 0.002）是年轻 CRVO 患者视力预后不良的显著危险因素。
与老年 CRVO 患者相比，年轻 CRVO 患者的临床病程较轻，治疗较少，且更有可能存在非传统危险因素。
