Zhang Xiao-Tong, Zhong Yi-Fan, Xue Yan-Qi, Li Si-Qi, Wang Bing-Yu, Zhang Gui-Qi, Hidasa Iko, Zhang Han
Department of Ophthalmology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, China.
Ophthalmol Ther. 2022 Aug;11(4):1409-1422. doi: 10.1007/s40123-022-00534-7. Epub 2022 Jun 13.
Retinal vein occlusion (RVO) is the second most common retinal vascular disease. Central RVO (CRVO), in which obstruction occurs posterior to the lamina cribrosa due to various causes, manifests with extensive venous tortuosity, dilatation of blood vessels in the four quadrants, and retinal hemorrhage. The presence of macular edema decreases visual acuity in patients with CRVO, especially in elderly patients with hypertension, hyperlipidemia, and diabetes. In the last decade, treatment modalities for CRVO have improved, with anti-vascular endothelial growth factor agents being widely used as treatment. However, there are cases of refractory or recurrent macular edema. Moreover, CRVO also occurs in young patients. This article reviews previous studies and case reports and summarizes the differences in etiological factors, clinical manifestations, treatment, and prognosis between young and elderly patients. Due to the low incidence of CRVO in young patients, clinical data from these age groups are limited. Hence, further studies are warranted to explore the differences between age groups to improve individualization of treatment of young patients.
视网膜静脉阻塞（RVO）是第二常见的视网膜血管疾病。中央视网膜静脉阻塞（CRVO）是由于各种原因导致筛板后阻塞，表现为广泛的静脉迂曲、四个象限血管扩张和视网膜出血。黄斑水肿的存在会降低CRVO患者的视力，尤其是患有高血压、高脂血症和糖尿病的老年患者。在过去十年中，CRVO的治疗方式有所改进，抗血管内皮生长因子药物被广泛用作治疗药物。然而，存在难治性或复发性黄斑水肿的病例。此外，CRVO也发生在年轻患者中。本文回顾了以往的研究和病例报告，总结了年轻患者和老年患者在病因、临床表现、治疗和预后方面的差异。由于年轻患者中CRVO的发病率较低，这些年龄组的临床数据有限。因此，有必要进一步研究以探索不同年龄组之间的差异，以改善年轻患者治疗的个体化。
