Gill M A, DuBé J E, Young W W
Am J Hosp Pharm. 1977 May;34(5):528-31.
A case of hypokalemic metabolic alkalosis precipitated by high-dose intravenous ampicillin sodium is discussed. Cases of hypokalemic metabolic alkalosis attributable to ampicillin sodium have not been reported previously. There have been reports of this phenomenon associated with high doses of penicillin sodium and carbenicillin disodium. The possible mechanism of antibiotic-induced hypokalemic metabolic alkalosis is discussed. It is suggested that most cases of antibiotic-induced hypokalemia respond to oral or intravenous potassium chloride.
本文讨论了一例因大剂量静脉注射氨苄西林钠引发的低钾血症性代谢性碱中毒病例。此前尚未有因氨苄西林钠导致低钾血症性代谢性碱中毒的病例报道。有关于高剂量青霉素钠和羧苄西林二钠引发此现象的报道。文中讨论了抗生素诱发低钾血症性代谢性碱中毒的可能机制。建议大多数抗生素诱发的低钾血症病例可通过口服或静脉注射氯化钾来治疗。
