博茨瓦纳CD4细胞计数为100 - 200个/微升的人类免疫缺陷病毒（HIV）阳性患者中进行隐球菌抗原（CrAg）反射性筛查的结果
Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana.
作者信息
Tenforde Mark W, Milton Thandi, Rulaganyang Ikanyeng, Muthoga Charles, Tawe Leabaneng, Chiller Tom, Greene Gregory, Jordan Alexander, Williams Christopher G, Owen Leah, Leeme Tshepo B, Boose Amber, Ngidi Julia, Mine Madisa, Jarvis Joseph N
机构信息
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA.
出版信息
Clin Infect Dis. 2021 May 4;72(9):1635-1638. doi: 10.1093/cid/ciaa899.
Abstract
Increasing the CD4-count threshold for cryptococcal antigen (CrAg) screening from ≤100 to ≤200 cells/µL resulted in a 3-fold increase in numbers screened. CrAg-prevalence was 3.5% at CD4 101-200 and 6.2% ≤100 cells/µL. Six-month mortality was 21.4% (9/42) in CrAg-positive CD4 ≤100 cells/µL and 3.2% (1/31) in CrAg-positive CD4 101-200 cells/µL.
摘要
将隐球菌抗原（CrAg）筛查的CD4细胞计数阈值从≤100个细胞/µL提高到≤200个细胞/µL，导致筛查人数增加了两倍。CD4为101 - 200时CrAg患病率为3.5%，CD4≤100个细胞/µL时为6.2%。CD4≤100个细胞/µL的CrAg阳性患者6个月死亡率为21.4%（9/42），CD4为101 - 200个细胞/µL的CrAg阳性患者为3.2%（1/31）。
相似文献
1
Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana.博茨瓦纳CD4细胞计数为100 - 200个/微升的人类免疫缺陷病毒（HIV）阳性患者中进行隐球菌抗原（CrAg）反射性筛查的结果
Clin Infect Dis. 2021 May 4;72(9):1635-1638. doi: 10.1093/cid/ciaa899.
2
Prevalence and Sequelae of Cryptococcal Antigenemia in Antiretroviral Therapy-Experienced Populations: An Evaluation of Reflex Cryptococcal Antigen Screening in Botswana.接受抗逆转录病毒治疗人群中隐球菌抗原血症的患病率及后遗症：博茨瓦纳反射性隐球菌抗原筛查评估
Clin Infect Dis. 2021 May 18;72(10):1745-1754. doi: 10.1093/cid/ciaa356.
3
Cryptococcal antigen prevalence in HIV-infected Tanzanians: a cross-sectional study and evaluation of a point-of-care lateral flow assay.HIV 感染者中隐球菌抗原的流行情况：一项横断面研究和一种即时侧向流检测方法的评估。
Trop Med Int Health. 2013 Sep;18(9):1075-1079. doi: 10.1111/tmi.12157.
4
Prevalence, correlates, and outcomes of cryptococcal antigen positivity among patients with AIDS, United States, 1986-2012.1986 - 2012年美国艾滋病患者中隐球菌抗原阳性的患病率、相关因素及转归
Clin Infect Dis. 2015 Mar 15;60(6):959-65. doi: 10.1093/cid/ciu937. Epub 2014 Nov 24.
5
Asymptomatic cryptococcal antigen prevalence detected by lateral flow assay in hospitalised HIV-infected patients in São Paulo, Brazil.巴西圣保罗住院的HIV感染患者中通过侧向流动分析法检测到的无症状隐球菌抗原流行率。
Trop Med Int Health. 2016 Dec;21(12):1539-1544. doi: 10.1111/tmi.12790. Epub 2016 Oct 24.
6
CD4 Cell Count Threshold for Cryptococcal Antigen Screening of HIV-Infected Individuals: A Systematic Review and Meta-analysis.CD4 细胞计数阈值用于 HIV 感染个体的隐球菌抗原筛查：系统评价和荟萃分析。
Clin Infect Dis. 2018 Mar 4;66(suppl_2):S152-S159. doi: 10.1093/cid/cix1143.
7
Evaluation of a national cryptococcal antigen screening program for HIV-infected patients in Uganda: A cost-effectiveness modeling analysis.评估乌干达 HIV 感染患者的国家隐球菌抗原筛查计划：成本效益建模分析。
PLoS One. 2019 Jan 10;14(1):e0210105. doi: 10.1371/journal.pone.0210105. eCollection 2019.
8
Cryptococcal antigenemia is associated with meningitis or death in HIV-infected adults with CD4 100-200 cells/mm.隐球菌抗原血症与 CD4 细胞计数为 100-200 个/立方毫米的 HIV 感染成人的脑膜炎或死亡相关。
BMC Infect Dis. 2020 Jan 20;20(1):61. doi: 10.1186/s12879-020-4798-1.
9
High Cryptococcal Antigen Titers in Blood Are Predictive of Subclinical Cryptococcal Meningitis Among Human Immunodeficiency Virus-Infected Patients.血液中高隐球菌抗原滴度可预测人类免疫缺陷病毒感染患者的无症状隐球菌性脑膜炎。
Clin Infect Dis. 2018 Feb 10;66(5):686-692. doi: 10.1093/cid/cix872.
10
Evaluation of screening and treatment of cryptococcal antigenaemia among HIV-infected persons in Soweto, South Africa.南非索韦托地区艾滋病毒感染者隐球菌抗原血症的筛查与治疗评估
HIV Med. 2015 Sep;16(8):468-76. doi: 10.1111/hiv.12245. Epub 2015 Feb 17.
引用本文的文献
1
Screening for cryptococcal antigenemia and meningeal cryptococcosis, genetic characterization of Cryptococcus neoformans in asymptomatic patients with advanced HIV disease in Kinshasa, Democratic Republic of Congo.刚果民主共和国金沙萨晚期HIV疾病无症状患者的隐球菌抗原血症和脑膜隐球菌病筛查及新型隐球菌的基因特征分析
Sci Rep. 2024 Dec 2;14(1):29959. doi: 10.1038/s41598-024-80772-w.
2
Tracking Cryptococcal Meningitis to Monitor HIV Program Success During the Treat All Era: An Analysis of National Data in Botswana.在全民治疗时代追踪新型隐球菌性脑膜炎以监测艾滋病毒规划的成功：博茨瓦纳国家数据的分析。
Clin Infect Dis. 2024 Aug 16;79(2):462-468. doi: 10.1093/cid/ciae066.
3
Five years after Treat All implementation: Botswana's HIV response and future directions in the era of COVID-19.全面治疗实施五年后：博茨瓦纳应对艾滋病病毒的措施及新冠疫情时代的未来方向
South Afr J HIV Med. 2021 Oct 15;22(1):1275. doi: 10.4102/sajhivmed.v22i1.1275. eCollection 2021.
4
Asymptomatic cryptococcal antigenemia in HIV-infected patients: a review of recent studies.HIV感染患者的无症状隐球菌抗原血症：近期研究综述
Chin Med J (Engl). 2020 Dec 5;133(23):2859-2866. doi: 10.1097/CM9.0000000000001134.
本文引用的文献
1
Prevalence and Sequelae of Cryptococcal Antigenemia in Antiretroviral Therapy-Experienced Populations: An Evaluation of Reflex Cryptococcal Antigen Screening in Botswana.接受抗逆转录病毒治疗人群中隐球菌抗原血症的患病率及后遗症：博茨瓦纳反射性隐球菌抗原筛查评估
Clin Infect Dis. 2021 May 18;72(10):1745-1754. doi: 10.1093/cid/ciaa356.
2
HIV-Associated Cryptococcal Meningitis Occurring at Relatively Higher CD4 Counts.HIV 相关隐球菌性脑膜炎在相对较高的 CD4 计数时发生。
J Infect Dis. 2019 Feb 23;219(6):877-883. doi: 10.1093/infdis/jiy602.
3
Impact of Routine Cryptococcal Antigen Screening and Targeted Preemptive Fluconazole Therapy in Antiretroviral-naive Human Immunodeficiency Virus-infected Adults With CD4 Cell Counts <100/μL: A Systematic Review and Meta-analysis.抗逆转录病毒治疗初治的 CD4 细胞计数<100/μL 的人类免疫缺陷病毒感染成人中，常规隐球菌抗原筛查和目标性抢先氟康唑治疗的影响：系统评价和荟萃分析。
Clin Infect Dis. 2019 Feb 1;68(4):688-698. doi: 10.1093/cid/ciy567.
4
CD4 Cell Count Threshold for Cryptococcal Antigen Screening of HIV-Infected Individuals: A Systematic Review and Meta-analysis.CD4 细胞计数阈值用于 HIV 感染个体的隐球菌抗原筛查：系统评价和荟萃分析。
Clin Infect Dis. 2018 Mar 4;66(suppl_2):S152-S159. doi: 10.1093/cid/cix1143.
5
High Cryptococcal Antigen Titers in Blood Are Predictive of Subclinical Cryptococcal Meningitis Among Human Immunodeficiency Virus-Infected Patients.血液中高隐球菌抗原滴度可预测人类免疫缺陷病毒感染患者的无症状隐球菌性脑膜炎。
Clin Infect Dis. 2018 Feb 10;66(5):686-692. doi: 10.1093/cid/cix872.
6
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.HIV 相关隐球菌性脑膜炎的全球疾病负担：最新分析
Lancet Infect Dis. 2017 Aug;17(8):873-881. doi: 10.1016/S1473-3099(17)30243-8. Epub 2017 May 5.
7
Lumbar puncture refusal in sub-Saharan Africa: A call for further understanding and intervention.撒哈拉以南非洲地区腰椎穿刺术的拒绝现象：呼吁进一步了解与干预。
Neurology. 2015 May 12;84(19):1988-90. doi: 10.1212/WNL.0000000000001561.
8
Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial.在坦桑尼亚和赞比亚，对开始接受抗逆转录病毒治疗的晚期 HIV 感染患者进行隐球菌性脑膜炎筛查和基于社区的早期依从性支持：一项开放标签、随机对照试验。
Lancet. 2015 May 30;385(9983):2173-82. doi: 10.1016/S0140-6736(15)60164-7. Epub 2015 Mar 10.
9
Screening for cryptococcal antigenemia in patients accessing an antiretroviral treatment program in South Africa.在南非接受抗逆转录病毒治疗项目的患者中进行隐球菌抗原血症筛查。
Clin Infect Dis. 2009 Apr 1;48(7):856-62. doi: 10.1086/597262.
Zotero 插件