University of Tours, Tours, France.
Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, CNRS/Universite de Bordeaux, Bordeaux, France.
Semin Thromb Hemost. 2020 Jul;46(5):563-586. doi: 10.1055/s-0039-1701019. Epub 2020 Jun 30.
Atherosclerosis is the major underlying cause of cardiovascular diseases, the prevalence of which is continuously increasing, thus currently standing as the leading global cause of death. This pathology gradually develops over the course of 50 or more years throughout the life of an individual under the influence of a vast number of factors, both environmental and pathophysiological. This wealth of factors has elicited much research into molecular imaging, with purely diagnostic purposes or with the hope of engineering an efficient theranostic tool. To these ends, diverse nanomaterials with desirable, tunable properties have been explored by different teams, as described in this review.
动脉粥样硬化是心血管疾病的主要潜在原因,其患病率不断上升,因此目前是全球主要的死亡原因。这种病理学在个体的一生中,在大量环境和病理生理因素的影响下,经过 50 年或更长时间逐渐发展。这些因素促使人们对分子成像进行了大量研究,其目的既有纯粹的诊断,也有工程高效治疗诊断工具的希望。为此,不同的团队探索了具有理想可调特性的各种纳米材料,正如这篇综述所述。