Palekar Rohun U, Jallouk Andrew P, Lanza Gregory M, Pan Hua, Wickline Samuel A
Department of Biomedical Engineering, Washington University, Whitaker Hall, Campus Box 1097, One Brookings Drive, St. Louis, MO 63130, USA.
Department of Medicine, Washington University, Campus Box 8215, 4320 Forest Park Avenue, St Louis, MO 63108, USA.
Nanomedicine (Lond). 2015;10(11):1817-32. doi: 10.2217/nnm.15.26.
As atherosclerosis remains one of the most prevalent causes of patient mortality, the ability to diagnose early signs of plaque rupture and thrombosis represents a significant clinical need. With recent advances in nanotechnology, it is now possible to image specific molecular processes noninvasively with MRI, using various types of nanoparticles as contrast agents. In the context of cardiovascular disease, it is possible to specifically deliver contrast agents to an epitope of interest for detecting vascular inflammatory processes, which serve as predecessors to atherosclerotic plaque development. Herein, we review various applications of nanotechnology in detecting atherosclerosis using MRI, with an emphasis on perfluorocarbon nanoparticles and fluorine imaging, along with theranostic prospects of nanotechnology in cardiovascular disease.
由于动脉粥样硬化仍然是患者死亡的最常见原因之一，诊断斑块破裂和血栓形成早期迹象的能力具有重大临床需求。随着纳米技术的最新进展，现在可以使用各种类型的纳米颗粒作为造影剂，通过磁共振成像（MRI）对特定分子过程进行无创成像。在心血管疾病的背景下，可以将造影剂特异性地递送至感兴趣的表位，以检测血管炎症过程，而血管炎症过程是动脉粥样硬化斑块发展的先兆。在此，我们综述了纳米技术在利用MRI检测动脉粥样硬化中的各种应用，重点介绍了全氟碳纳米颗粒和氟成像，以及纳米技术在心血管疾病中的诊疗前景。
