Silverstein Todd P
Chemistry Department (emeritus), Willamette University, Salem, Oregon, USA.
Biochem Mol Biol Educ. 2020 Sep;48(5):452-459. doi: 10.1002/bmb.21397. Epub 2020 Jun 30.
The Hill equation, which models the cooperative ligand-receptor binding equilibrium, turns out to be useful in modeling the progression of infectious disease outbreaks such as CoViD-19. The equation fits well the data for total and daily case numbers, allows tentative predictions for the half-point and end point of the epidemic, and presents a mathematical characterization of how social interventions "flatten the curve" of the disease progression.
希尔方程用于模拟配体 - 受体结合的协同平衡,结果证明它在模拟COVID - 19等传染病爆发的进展方面很有用。该方程能很好地拟合累计病例数和每日病例数的数据,可对疫情的中点和终点进行初步预测,并给出了社会干预如何“ flatten the curve”(使曲线平缓,常指减缓疫情传播速度)的疾病进展的数学特征。