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酶学虚拟实验室课程

Virtual laboratory lessons in enzymology.

作者信息

Quesada Víctor

机构信息

Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, Oviedo, Spain.

Centro de Investigación Biomédica en Red, Ciberonc, Madrid, Spain.

出版信息

Biochem Mol Biol Educ. 2020 Sep;48(5):442-447. doi: 10.1002/bmb.21394. Epub 2020 Jun 30.

Abstract

The recent COVID-19 pandemic has led to widespread lock-down strategies that force universities to perform all educational activities remotely. In this context, laboratory lessons pose a significant challenge. Here, I present an on-line tool that simulates the kinetics of chemical reactions. Enzymatic mechanisms can be easily modeled and followed through time. In addition, professors can customize the interface to hide the reaction mechanism. This setting will force students to design virtual experiments to uncover the mechanism and obtain the relevant enzymatic parameters. While some of the skills developed in a practical lesson cannot be simulated, this tool can be used to teach students important concepts about data acquisition and processing.

摘要

近期的新冠疫情导致了广泛的封锁措施,迫使大学将所有教学活动转为线上进行。在此背景下,实验课程面临着巨大挑战。在此,我介绍一种模拟化学反应动力学的在线工具。酶促机制能够轻松建模并随时间追踪。此外,教授可以定制界面以隐藏反应机制。这种设置将促使学生设计虚拟实验来揭示机制并获取相关的酶学参数。虽然实践课程中培养的一些技能无法模拟,但该工具可用于教授学生有关数据采集和处理的重要概念。

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