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脊髓刺激对继发于脊髓病的痉挛和抽搐的影响。

Effects of spinal cord stimulation on spasticity and spasms secondary to myelopathy.

作者信息

Barolat G, Myklebust J B, Wenninger W

机构信息

Department of Neurosurgery, Jefferson Medical College, Philadelphia, Pa.

出版信息

Appl Neurophysiol. 1988;51(1):29-44. doi: 10.1159/000099381.

Abstract

16 subjects with severe spasms secondary to traumatic and nontraumatic myelopathy underwent epidural spinal cord stimulation. 4 patients had a complete motor and sensory spinal cord lesion. 6 of the subjects with an incomplete spinal cord lesion were ambulatory. All patients had previously undergone extensive trials with medications and physical therapy. All 14 subjects in whom a satisfactory placement of the electrode could be obtained had a reduction in the severity of the spasms. In 6 patients, the spasms were almost abolished. Extremity, trunkal and abdominal spasms were affected. Clonus in the upper extremities was consistently reduced. Marked improvement in bladder and bowel function was observed in each of 2 subjects. In over 1-year follow-up, 5 subjects show persistence of the results, with less stimulation required to maintain the therapeutic effects. No neurological deterioration occurred following the procedure or after long-term spinal stimulation. 1 patient showed after several months of continuous stimulation increased voluntary motor control present only when spinal cord stimulation was activated. Complications included 1 system infection, 1 electrode migration, 1 wire breakage and skin breakdown at a connector site, development of high impedance in 1 electrode and 1 skin breakdown over the lead.

摘要

16例继发于创伤性和非创伤性脊髓病的严重痉挛患者接受了硬膜外脊髓刺激。4例患者存在完全性运动和感觉脊髓损伤。6例不完全性脊髓损伤患者可独立行走。所有患者此前均接受过广泛的药物和物理治疗试验。在所有14例能够成功放置电极的患者中,痉挛严重程度均有所减轻。6例患者的痉挛几乎完全消除。肢体、躯干和腹部痉挛均受到影响。上肢阵挛持续减轻。2例患者的膀胱和肠道功能均有显著改善。在超过1年的随访中,5例患者的治疗效果持续存在,维持治疗效果所需的刺激减少。术后及长期脊髓刺激后均未发生神经功能恶化。1例患者在持续刺激数月后,仅在激活脊髓刺激时出现了自主运动控制增加。并发症包括1例系统感染、1例电极移位、1例导线断裂、1例连接器部位皮肤破损、1例电极出现高阻抗以及1例导线部位皮肤破损。

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