颈脊髓损伤后非侵入性脊髓刺激的多系统益处：一项病例研究
Multi-system benefits of non-invasive spinal cord stimulation following cervical spinal cord injury: a case study.
作者信息
Samejima Soshi, Shackleton Claire, Malik Raza N, Hosseinzadeh Ali, Rempel Lucas, Phan Anh-Duong, Williams Alison, Nightingale Tom, Ghuman Amandeep, Elliott Stacy, Walter Matthias, Krogh Klaus, Berger Michael, Lam Tania, Sachdeva Rahul, Krassioukov Andrei V
机构信息
International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Division of Physical Medicine and Rehabilitation, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
出版信息
Bioelectron Med. 2025 Sep 5;11(1):20. doi: 10.1186/s42234-025-00183-8.
UNLABELLED
Cervical spinal cord injury (SCI) impairs sensorimotor and autonomic functions. We investigated the effects of lumbosacral transcutaneous spinal cord stimulation (tSCS) on urinary bladder, bowel, and sexual function as well as cardiovascular and sensorimotor functions in one individual with chronic clinically motor-complete cervical SCI, 11 years post-injury. Following 30 sessions of lumbosacral tSCS, the individual presented with improved urinary bladder compliance as well as anorectal function in parallel with mitigation of the severity of autonomic dysreflexia during filling cystometry and anorectal manometry. In addition, long-term tSCS improved erectile function and sexual satisfaction. Furthermore, after long-term tSCS, concurrent tSCS enabled voluntary leg movement. This case study demonstrated the multi-system benefits of lumbosacral tSCS, which holds promise for evolving into a clinically viable therapy for restoring both autonomic and motor functions following SCI.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1186/s42234-025-00183-8.
未标注
颈脊髓损伤（SCI）会损害感觉运动和自主神经功能。我们研究了腰骶部经皮脊髓刺激（tSCS）对一名慢性临床运动完全性颈脊髓损伤患者（受伤11年后）的膀胱、肠道和性功能以及心血管和感觉运动功能的影响。在进行30次腰骶部tSCS治疗后，该患者膀胱顺应性改善，同时直肠肛门功能改善，在膀胱测压和直肠肛门测压期间自主神经反射异常的严重程度减轻。此外，长期tSCS改善了勃起功能和性满意度。此外，长期tSCS后，同步tSCS使患者能够自主进行腿部运动。本病例研究证明了腰骶部tSCS的多系统益处，有望发展成为一种临床上可行的疗法，用于恢复脊髓损伤后的自主神经和运动功能。
补充信息
在线版本包含可在10.1186/s42234-025-00183-8获取的补充材料。
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