Tahara E, Yokozaki H
Dept. of Pathology, Hiroshima University School of Medicine.
Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-1):1102-8.
The expressions of epidermal growth factor (EGF), EGF receptor, transforming growth factor (TGF) alpha and c-Ha-ras p21 in human gastric carcinomas were studied immunohistochemically. Any of these four marker proteins from gastric tumor cells was closely correlated with the depth of tumor invasion. The incidences of cases with EGF or synchronous expression of TGF alpha and c-Ha-ras in metastatic tumors were significantly higher than those in primary tumors (p less than 0.05 or p less than 0.01). Patients with synchronous expression of EGF and its receptor or TGF alpha and ras p21 had a far poorer prognosis than those without such synchronous expression. These findings strongly suggest that the EGF-related growth factors, EGF-receptor and ras p21 mutually play an important role in tumor progression and could be useful as potential metastatic and/or prognostic markers for gastric carcinoma.
采用免疫组织化学方法研究了人胃癌中表皮生长因子（EGF）、EGF受体、转化生长因子（TGF）α和c-Ha-ras p21的表达情况。胃肿瘤细胞中的这四种标记蛋白中的任何一种都与肿瘤浸润深度密切相关。转移瘤中EGF或TGFα与c-Ha-ras同步表达的病例发生率明显高于原发肿瘤（p<0.05或p<0.01）。EGF及其受体或TGFα与ras p21同步表达的患者预后比未同步表达的患者差得多。这些发现强烈表明，EGF相关生长因子、EGF受体和ras p21在肿瘤进展中相互发挥重要作用，可作为胃癌潜在的转移和/或预后标志物。
