Yamamoto T, Hattori T, Tahara E
Department of Surgery, Hiroshima University, Japan.
Pathol Res Pract. 1988 Nov;183(6):663-9. doi: 10.1016/S0344-0338(88)80050-5.
The expression of TGF alpha and c-Ha-ras p21 was studied immunohistochemically in a total of 174 gastric carcinomas, comprising 27 early carcinomas and 147 advanced carcinomas. TGF alpha-immunoreactivity was detected in 7 (25.9%) of the 27 early carcinomas and in 110 (74.8%) of the 147 advanced carcinomas, the incidence being significantly different between the two (P less than 0.01). Out of the 67 c-Ha-ras p21 positive carcinomas, 59 (88.1%) showed TGF alpha-immunoreactivity synchronously. A significant positive correlation was observed between the grade of TGF alpha and incidence of c-Ha-ras p21-immunoreactivity in tumor cells (P less than 0.01). Furthermore, a good correlation was demonstrated between synchronous expression of TGF alpha and c-Ha-ras p21 and depth of tumor invasion (P less than 0.01). The incidence of synchronous expression of TGF alpha and c-Ha-ras p21 in metastatic tumors was significantly higher than that in primary tumors showing no lymphatic metastasis (P less than 0.01). Patients with carcinomas showing synchronous expression of TGF alpha and c-Ha-ras p21 had an extremely poorer prognosis than those without TGF alpha and c-Ha-ras p21. These results indicate that the synchronous expression of TGF alpha and c-Ha-ras p21 plays an important role in high malignancy of gastric carcinomas.
采用免疫组织化学方法研究了174例胃癌中转化生长因子α（TGFα）和c-Ha-ras p21的表达情况，其中包括27例早期胃癌和147例进展期胃癌。在27例早期胃癌中有7例（25.9%）检测到TGFα免疫反应性，在147例进展期胃癌中有110例（74.8%）检测到，两者发生率有显著差异（P<0.01）。在67例c-Ha-ras p21阳性的胃癌中，59例（88.1%）同时显示TGFα免疫反应性。肿瘤细胞中TGFα分级与c-Ha-ras p21免疫反应性发生率之间存在显著正相关（P<0.01）。此外，TGFα和c-Ha-ras p21的同步表达与肿瘤浸润深度之间也显示出良好的相关性（P<0.01）。转移瘤中TGFα和c-Ha-ras p21同步表达的发生率显著高于无淋巴转移的原发肿瘤（P<0.01）。TGFα和c-Ha-ras p21同步表达的胃癌患者预后比无TGFα和c-Ha-ras p21表达的患者极差。这些结果表明，TGFα和c-Ha-ras p21的同步表达在胃癌的高恶性中起重要作用。
