Department of Occupational and Environmental Health, Graduate School of Medical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Aichi 4678601, Japan.
Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba 2701695, Japan.
Int J Environ Res Public Health. 2020 Jun 26;17(12):4608. doi: 10.3390/ijerph17124608.
The effects of prenatal exposure to household pesticides on fetal and neonatal growth have not been fully clarified. The present study aims to determine the effects of prenatal exposure to pesticides on neonates' body size and growth during the first month. This study included 93,718 pairs of pregnant women and their children from the Japan Environment and Children's Study. Participants completed self-reporting questionnaires during their second or third trimesters on their demographic characteristics and frequency of pesticide use during pregnancy. Child weight, length, and sex were obtained from medical record transcripts. Birth weight and length, as well as weight and length changes over the first month, were estimated using an analysis of covariance. Frequency of exposure to almost all pesticides had no effects on birth weight and length. However, we found small but significant associations (i) between the use of fumigation insecticides and decreased birth weight, and (ii) between frequencies of exposure to pyrethroid pesticides, especially mosquito coils/mats, and suppression of neonatal length growth. Prenatal exposure to household pesticides, especially those containing pyrethroids, might adversely influence fetal and postnatal growth trajectories.
产前暴露于家用杀虫剂对胎儿和新生儿生长的影响尚未完全阐明。本研究旨在确定产前暴露于杀虫剂对新生儿出生后第一个月内体型和生长的影响。该研究纳入了来自日本环境与儿童研究的 93718 对孕妇及其子女。参与者在妊娠中期或晚期完成了关于人口统计学特征和妊娠期间杀虫剂使用频率的自我报告问卷。儿童的体重、长度和性别从医疗记录转录中获得。使用协方差分析估计出生体重和长度，以及出生后第一个月体重和长度的变化。几乎所有杀虫剂的暴露频率均与出生体重和长度无关。然而，我们发现使用熏蒸杀虫剂与出生体重降低之间存在小但显著的关联，以及接触拟除虫菊酯类杀虫剂（尤其是蚊香/垫）的频率与新生儿长度生长抑制之间存在关联。产前暴露于家用杀虫剂，尤其是含有拟除虫菊酯类的杀虫剂，可能会对胎儿和产后生长轨迹产生不利影响。
