[静脉注射离子型和非离子型放射造影剂对激肽释放酶-激肽系统的激活作用]

[Activation of the kallikrein-kinin system by intravenous administration of ionic and non-ionic radiographic contrast media].

作者信息

Hoffmeister H M, Fuhrer G, Abels G A, Pirschel J, Heller W

机构信息

Medizinische Klinik, Abteilung III, Universität Tübingen.

出版信息

Dtsch Med Wochenschr. 1988 Jul 15;113(28-29):1138-41. doi: 10.1055/s-2008-1067782.

DOI:10.1055/s-2008-1067782

PMID:3260554

Abstract

Conventional ionic contrast media (sodium meglumine and amidotrizoate) were injected intravenously in 22 patients (group A); the nonionic, low-osmolar contrast medium iohexol was similarly administered to 24 patients (group B). This resulted in a significant (group A: P less than 0.05; group B: P less than 0.01) reduction in prekallikrein (93 and 94%, respectively), inhibition of kallikrein (90 and 88%), beta-factor XIIa inhibition (86 and 85%), and C1 inhibition (90 and 91%). Factor XII levels remained unchanged in both groups. These results indicate that the kallikrein-kinin system is activated even during routine, complication-free radiographic procedures involving contrast-media injection. There was no difference between ionic and nonionic contrast media.

摘要

对22例患者（A组）静脉注射传统离子型造影剂（葡甲胺和泛影酸盐）；对24例患者（B组）同样静脉注射非离子型低渗造影剂碘海醇。结果显示，前激肽释放酶显著降低（A组：P<0.05；B组：P<0.01），分别降低了93%和94%，激肽释放酶受到抑制（90%和88%），β-因子XIIa受到抑制（86%和85%），C1受到抑制（90%和91%）。两组的因子XII水平均保持不变。这些结果表明，即使在涉及注射造影剂的常规、无并发症的放射学检查过程中，激肽释放酶-激肽系统也会被激活。离子型和非离子型造影剂之间没有差异。