小鼠促肾上腺皮质激素释放因子在大鼠中诱导的局部癫痫样活动。

Localized epileptiform activity induced by murine CRF in rats.

作者信息

Marrosu F, Fratta W, Carcangiu P, Giagheddu M, Gessa G L

机构信息

Institute of Neurology, University of Cagliari, Italy.

出版信息

Epilepsia. 1988 Jul-Aug;29(4):369-73. doi: 10.1111/j.1528-1157.1988.tb03733.x.

DOI:10.1111/j.1528-1157.1988.tb03733.x

PMID:3260555

Abstract

Murine corticotropin releasing factor (rCRF), injected intracerebroventricularly into rats at a dose of 10 micrograms produced increased motor activity, grooming, and recurrent episodes of epileptic activity localized in the hippocampal leads. Such activity persisted for approximately 5 h and was characterized by recurrent trains of biphasic spikes never associated with behavioral signs of epilepsy. The intraperitoneal administration of carbamazepine (15 and 30 mg/kg) reduced the epileptic activity for approximately 90 and 120 min, respectively, whereas that of naloxone (8 mg/kg) was ineffective. The results suggest that rCRF-induced spiking activity might be a model of temporal lobe epilepsy.

摘要

将鼠促肾上腺皮质激素释放因子（rCRF）以10微克的剂量脑室内注射到大鼠体内，会使运动活性增强、出现理毛行为，并且在海马导联中出现反复的癫痫样活动发作。这种活动持续约5小时，其特征是反复出现的双相尖峰序列，从未伴有癫痫的行为体征。腹腔注射卡马西平（15和30毫克/千克）分别使癫痫样活动减少约90分钟和120分钟，而注射纳洛酮（8毫克/千克）则无效。结果表明，rCRF诱导的尖峰活动可能是颞叶癫痫的一种模型。