Krahn D D, Gosnell B A, Levine A S, Morley J E
Department of Psychiatry, University of Michigan, Ann Arbor 48109-0116.
Brain Res. 1988 Mar 8;443(1-2):63-9. doi: 10.1016/0006-8993(88)91598-3.
Corticotropin-releasing factor (CRF) has potent behavioral effects when administered intracerebroventricularly to rats. CRF and its receptors are found in an uneven distribution in the brain. In an effort to localize the site of the anorectic effect of CRF, exogenous CRF or saline was injected into cannulas directed toward the paraventricular hypothalamic nucleus (PVN), lateral hypothalamus, ventromedial hypothalamus, globus pallidus, or striatum of rats. CRF decreased food intake only when injected into the PVN. In subsequent experiments PVN injections of CRF were shown to (1) increase grooming and movement; (2) not induce a conditioned taste aversion to saccharin in a single bottle test; and (3) inhibit the increase in feeding induced by injections of norepinephrine into the PVN. These results suggest that CRF induces not only anorexia, but also increased movement and grooming by action in the PVN.
当向大鼠脑室内注射促肾上腺皮质激素释放因子（CRF）时，它会产生显著的行为效应。CRF及其受体在大脑中呈不均匀分布。为了确定CRF厌食效应的作用位点，将外源性CRF或生理盐水注射到插入大鼠下丘脑室旁核（PVN）、下丘脑外侧区、下丘脑腹内侧核、苍白球或纹状体的套管中。只有当CRF注射到PVN时才会减少食物摄入量。在随后的实验中，向PVN注射CRF被证明：（1）增加梳理毛发和活动；（2）在单瓶试验中不会诱导对糖精的条件性味觉厌恶；（3）抑制向PVN注射去甲肾上腺素所诱导的进食增加。这些结果表明，CRF不仅通过在PVN中的作用诱导厌食，还会增加活动和梳理毛发行为。
