急性缺血性脑卒中住院期间的胃肠道出血会增加脑卒中复发的风险。
Gastrointestinal bleeding during acute ischaemic stroke hospitalisation increases the risk of stroke recurrence.
机构信息
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beiing, China.
出版信息
Stroke Vasc Neurol. 2020 Jun;5(2):116-120. doi: 10.1136/svn-2019-000314. Epub 2020 Apr 8.
OBJECTIVE
Gastrointestinal (GI) bleeding in patients who had a stroke is strongly associated with a higher risk of death and loss of independence. However, it is unknown whether GI bleeding increases risk for recurrence of stroke. In this study, we assess the potential relationship between GI bleeding and stroke recurrence in patients within 12 months of an acute ischaemic stroke (AIS), using the China National Stroke Registry (CNSR).
METHODS
This study included 22 216 patients who had an ischaemic stroke included in the CNSR from 2007 to 2008. We analysed baseline patient characteristics, GI bleeding and outcomes of patients who had an AIS, specifically stroke recurrence at 3, 6 and 12 months. We used multivariable logistic regression to evaluate a possible association between GI bleeding and stroke recurrence.
RESULTS
Of the 12 415 patients included in our study, 12.3%, 15.5% and 17.7% had a stroke recurrence at 3, 6 and 12 months, respectively. GI bleeding was an independent stroke recurrence risk factor in patients after ischaemic stroke at 3 months (adjusted OR 1.481, 95% CI 1.118 to 1.962), 6 months (adjusted OR 1.448, 95% CI 1.106 to 1.896) and 12 months (adjusted OR 1.350; 95% CI 1.034 to 1.763).
CONCLUSION
GI bleeding was associated with the increased risk of stroke recurrence after an AIS.
目的
患有中风的患者发生胃肠道（GI）出血与更高的死亡风险和丧失独立性密切相关。然而，目前尚不清楚胃肠道出血是否会增加中风复发的风险。在这项研究中，我们使用中国国家中风登记处（CNSR）评估了 12 个月内急性缺血性中风（AIS）患者胃肠道出血与中风复发之间的潜在关系。
方法
这项研究纳入了 2007 年至 2008 年 CNSR 中纳入的 22216 例缺血性中风患者。我们分析了基线患者特征、AIS 患者的胃肠道出血情况以及结局，特别是 3、6 和 12 个月时的中风复发情况。我们使用多变量逻辑回归来评估胃肠道出血与中风复发之间可能存在的关联。
结果
在我们的研究中，纳入的 12415 例患者中，分别有 12.3%、15.5%和 17.7%在 3、6 和 12 个月时复发中风。胃肠道出血是缺血性中风后 3 个月（调整后的 OR 1.481，95%CI 1.118 至 1.962）、6 个月（调整后的 OR 1.448，95%CI 1.106 至 1.896）和 12 个月（调整后的 OR 1.350；95%CI 1.034 至 1.763）时中风复发的独立危险因素。
结论
胃肠道出血与 AIS 后中风复发风险增加相关。
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