Cao Qiong-Yue, Li Zheng
School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, China.
Jiangsu Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, College of Health Sciences, School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, Jiangsu Province, China.
World J Clin Cases. 2024 Nov 16;12(32):6534-6537. doi: 10.12998/wjcc.v12.i32.6534.
In this editorial, we comment on a recent article which addressed the therapeutic effect of aspirin plus edaravone in patients with cerebral infarction (CI). Herein, we outline the progress in therapy of CI. Apart from thrombolysis, aspirin is the most effective treatment for CI. Edaravone, a free radical scavenger, reduces endothelial cell damage and delays neuronal cell death. Aspirin plus edaravone mitigates damage to brain tissue by different mechanisms, thereby expediting the reinstation of neurological function. However, the nephrotoxic effect of edaravone, along with gastrointestinal bleeding associated with aspirin, may restrict this combination therapy. Although clinical studies have demonstrated the efficacy of thrombolytic therapy and mechanical thrombectomy, patients receiving these treatments experience modest efficacy and many adverse events. Moreover, interest in exploring natural medicines for CI is increasing, and they appear to have a high potential to protect against CI. The evolution of therapeutic strategies is expected to improve clinical outcomes of patients with CI.
在这篇社论中，我们对最近一篇关于阿司匹林联合依达拉奉治疗脑梗死（CI）患者疗效的文章进行评论。在此，我们概述了脑梗死治疗的进展。除溶栓治疗外，阿司匹林是治疗脑梗死最有效的药物。依达拉奉作为一种自由基清除剂，可减少内皮细胞损伤并延缓神经元细胞死亡。阿司匹林联合依达拉奉通过不同机制减轻脑组织损伤，从而加速神经功能的恢复。然而，依达拉奉的肾毒性作用以及阿司匹林相关的胃肠道出血可能会限制这种联合治疗。尽管临床研究已证明溶栓治疗和机械取栓术的疗效，但接受这些治疗的患者疗效一般且会出现许多不良事件。此外，探索用于脑梗死的天然药物的兴趣日益增加，而且它们似乎具有预防脑梗死的巨大潜力。治疗策略的演变有望改善脑梗死患者的临床结局。
