白细胞端粒长度及其调节基因与口腔癌的关系。
Association of Leukocyte Telomere Length and Genes Involved in its Regulation With Oral Carcinoma.
机构信息
Medical Faculty, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Department of Prosthodontics, Lithuanian University of Health Sciences, Kaunas, Lithuania
出版信息
In Vivo. 2020 Jul-Aug;34(4):1739-1747. doi: 10.21873/invivo.11967.
BACKGROUND/AIM: This study aimed to determine the relationship between the relative leukocyte telomere length (RLTL) and gene polymorphisms involved in its regulation with the occurrence of oral squamous cell carcinoma (OSCC).
PATIENTS AND METHODS
Patients with OSCC and healthy subjects were examined. Genotyping and RLTL measurement were carried out using rPCR.
RESULTS
The OSCC group had longer telomeres than controls (p=0.001). Minor allele T at TERF1rs1545827 may increase RLTL shortening (p=0.047). TNKS2rs10509639 A/G and A/G+G/G genotypes were associated with a 2.6-fold increased odd (p=0.012) and a 2.4-fold increased odd (p=0.019) of RLTL elongation compared to A/A genotype. The A/G genotype was associated with a 2.6-fold increased odd (p=0.011) compared to the A/A+G/G genotypes. Each G allele was associated with a 2.1-fold increased odd of longer RLTL (p=0.036).
CONCLUSION
Longer telomeres were found in patients with OSCC than in controls. The TERF1 rs1545827 and the TNKS2 rs10509639 polymorphisms were associated with an increase in RLTL.
背景/目的：本研究旨在确定相对白细胞端粒长度（RLTL）与调节其的基因多态性与口腔鳞状细胞癌（OSCC）发生之间的关系。
患者和方法
检查了 OSCC 患者和健康受试者。使用 rPCR 进行基因分型和 RLTL 测量。
结果
OSCC 组的端粒比对照组长（p=0.001）。TERF1 rs1545827 的 T 等位基因可能会增加 RLTL 缩短（p=0.047）。TNKS2 rs10509639 的 A/G 和 A/G+G/G 基因型与 RLTL 延长的 odds 增加 2.6 倍（p=0.012）和 odds 增加 2.4 倍（p=0.019），与 A/A 基因型相比。与 A/A+G/G 基因型相比，A/G 基因型的 odds 增加了 2.6 倍（p=0.011）。每个 G 等位基因与 RLTL 更长的 odds 增加 2.1 倍（p=0.036）相关。
结论
与对照组相比，OSCC 患者的端粒较长。TERF1 rs1545827 和 TNKS2 rs10509639 多态性与 RLTL 的增加相关。
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