使用仓鼠颊囊模型的 3D 打印聚甲基丙烯酸甲酯树脂气管造口管的可行性研究。
A Feasibility Study for 3D-printed Poly(methyl methacrylate)-resin Tracheostomy Tube Using a Hamster Cheek Pouch Model.
机构信息
Institute of New Frontier Research Team, Hallym University, Hallym Clinical and Translation Science Institute, Chuncheon, Republic of Korea.
Nano-Bio Regenerative Medical Institute, School of Medicine, Hallym University, Chuncheon, Republic of Korea.
出版信息
In Vivo. 2020 Jul-Aug;34(4):1749-1758. doi: 10.21873/invivo.11968.
BACKGROUND/AIM: A three-dimensional (3D) printed tracheostomy tube has potential application for patients who require a specialized tube. The aim of this study was to evaluate the characteristics of various 3D printing materials and determine their use in producing 3D-printed tracheostomy tube.
MATERIALS AND METHODS
Mechanical, chemical, and microbiological in vivo changes in the scaffolds were analyzed using a hamster cheek pouch (HCP) model.
RESULTS
The poly methyl methacylate (PMMA)-resin showed superior pre- and post-insertion mechanical properties and a relatively consistent lower biofilm formation compared with other scaffolds. PMMA-resin was successfully 3D-printed with dimensional accuracy without a support system. The use of a 3D-printed PMMA tracheostomy tube in a rabbit trachea showed no definite signs of infection, allergy or foreign body reaction.
CONCLUSION
PMMA-resin can be proposed as an alternative for a 3D-printed tracheostomy tube material. In addition, we suggest HCPs as an in vivo model for evaluating indwelling medical devices.
背景/目的：三维（3D）打印气管套管具有为特殊患者提供定制化套管的应用潜力。本研究旨在评估各种 3D 打印材料的特性，并确定它们在 3D 打印气管套管中的应用。
材料和方法
利用仓鼠颊囊（HCP）模型分析支架的机械、化学和微生物体内变化。
结果
聚甲基丙烯酸甲酯（PMMA）树脂在插入前后具有优异的机械性能，与其他支架相比，生物膜形成相对一致地较低。PMMA 树脂可以成功地 3D 打印，具有尺寸精度，无需支撑系统。将 3D 打印的 PMMA 气管套管用于兔气管中，未见明确的感染、过敏或异物反应迹象。
结论
PMMA 树脂可作为 3D 打印气管套管材料的替代品。此外，我们建议 HCP 作为评估留置医疗器械的体内模型。
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