Hata Kentaro, Ikeda Hiroshi, Nagamatsu Yuki, Masaki Chihiro, Hosokawa Ryuji, Shimizu Hiroshi
Division of Oral Reconstruction and Rehabilitation, Department of Oral Functions, Kyushu Dental University, Kitakyushu 803-8580, Japan.
Division of Biomaterials, Department of Oral Functions, Kyushu Dental University, Kitakyushu 803-8580, Japan.
J Funct Biomater. 2022 Mar 15;13(1):32. doi: 10.3390/jfb13010032.
Poly(methyl methacrylate) (PMMA)-based resins have been conventionally used in dental prostheses owing to their good biocompatibility. However, PMMA-based resins have relatively poor mechanical properties. In the present study, a novel nanoporous silica filler was developed and introduced into PMMA-based resins to improve their mechanical properties. The filler was prepared by sintering a green body composed of silica and an organic binder, followed by grinding to a fine powder and subsequent silanization. The filler was added to photocurable PMMA-based resin, which was prepared from MMA, PMMA, ethylene glycol dimethacrylate, and a photo-initiator. The filler was characterized by scanning electron microscopy (SEM), X-ray diffraction analysis, nitrogen sorption porosimetry, and Fourier transform infrared (FT-IR) spectroscopy. The PMMA-based resins were characterized by SEM and FT-IR, and the mechanical properties (Vickers hardness, flexural modulus, and flexural strength) and physicochemical properties (water sorption and solubility) were evaluated. The results suggested that the filler consisted of microparticles with nanopores. The filler at 23 wt % was well dispersed in the PMMA-based resin matrix. The mechanical and physicochemical properties of the PMMA-based resin improved significantly with the addition of the developed filler. Therefore, such filler-loaded PMMA-based resins are potential candidates for improving the strength and durability of polymer-based crown and denture base.
基于聚甲基丙烯酸甲酯（PMMA）的树脂由于其良好的生物相容性，传统上一直用于牙科修复体。然而，基于PMMA的树脂机械性能相对较差。在本研究中，开发了一种新型纳米多孔二氧化硅填料，并将其引入基于PMMA的树脂中以改善其机械性能。该填料是通过烧结由二氧化硅和有机粘合剂组成的生坯，然后研磨成细粉并随后进行硅烷化制备的。将该填料添加到由甲基丙烯酸甲酯、聚甲基丙烯酸甲酯、乙二醇二甲基丙烯酸酯和光引发剂制备的光固化PMMA基树脂中。通过扫描电子显微镜（SEM）、X射线衍射分析、氮吸附孔隙率测定法和傅里叶变换红外（FT-IR）光谱对填料进行表征。通过SEM和FT-IR对基于PMMA的树脂进行表征，并评估其机械性能（维氏硬度、弯曲模量和弯曲强度）和物理化学性能（吸水率和溶解度）。结果表明，该填料由具有纳米孔的微粒组成。23 wt%的填料在基于PMMA的树脂基体中分散良好。添加所开发的填料后，基于PMMA的树脂的机械和物理化学性能得到显著改善。因此，这种填充有填料的基于PMMA的树脂是提高聚合物基冠和义齿基托强度和耐久性的潜在候选材料。
