Werle M J, Herrera A A
Department of Biological Sciences, University of Southern California, Los Angeles 90089-0371.
J Neurobiol. 1988 Jul;19(5):465-81. doi: 10.1002/neu.480190505.
The elimination of polyneuronal innervation (synapse elimination) that occurs following reinnervation was studied in sartorius muscles of adult Rana pipiens. The percentage of neuromuscular junctions that were polyneuronally innervated declined from 47% at 40-80 days after nerve crush to 22% at greater than 250 days after nerve crush. We measured the size, synaptic strength, and position of competing nerve terminals at identified dually innervated neuromuscular junctions at these two different periods of synapse elimination. Our goal was to determine if any of these parameters play a role in the competition between nerve terminals that ultimately results in the elimination of polyneuronal innervation. Our data support the hypothesis that polyneuronal innervation will persist if competing nerve terminals are of similar synaptic efficacies but will be eliminated if the competing terminals are of different synaptic efficacies. We also tested, but failed to find any evidence, that the spatial proximity of competing nerve terminals at the same synaptic site influences the elimination of polyneuronal innervation.
在成年北美豹蛙的缝匠肌中，研究了再支配后发生的多神经元支配的消除（突触消除）。多神经元支配的神经肌肉接头百分比从神经挤压后40 - 80天的47%下降到神经挤压后超过250天的22%。我们在突触消除的这两个不同时期，测量了已确定的双重支配神经肌肉接头处竞争神经末梢的大小、突触强度和位置。我们的目标是确定这些参数中的任何一个是否在最终导致多神经元支配消除的神经末梢竞争中起作用。我们的数据支持这样的假设：如果竞争神经末梢具有相似的突触效能，多神经元支配将持续存在，但如果竞争末梢具有不同的突触效能，多神经元支配将被消除。我们还进行了测试，但未找到任何证据表明同一突触部位竞争神经末梢的空间接近度会影响多神经元支配的消除。
