Mental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Transl Psychiatry. 2020 Jun 30;10(1):209. doi: 10.1038/s41398-020-00902-6.
We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia (SCZ) (n = 65,967), bipolar disorder (BD) (n = 41,653), autism spectrum disorder (ASD) (n = 46,350), attention deficit hyperactivity disorder (ADHD) (n = 55,374), and depression (DEP) (n = 688,809). After the meta-analysis, the number of genomic loci increased from 14 to 19 in ADHD, from 3 to 10 in ASD, from 45 to 57 in DEP, from 8 to 54 in BD, and from 64 to 87 in SCZ. We observed significant enrichment of overlapping genes among different disorders and identified a panel of cross-disorder genes. A total of seven genes were found being commonly associated with four out of five psychiatric conditions, namely GABBR1, GLT8D1, HIST1H1B, HIST1H2BN, HIST1H4L, KCNB1, and DCC. The SORCS3 gene was highlighted due to the fact that it was involved in all the five conditions of study. Analysis of correlations unveiled the existence of two clusters of related psychiatric conditions, SCZ and BD that were separate from the other three traits, and formed another group. Our results may provide a new insight for genetic basis of the five psychiatric disorders.
我们对精神分裂症（SCZ）（n=65967）、双相情感障碍（BD）（n=41653）、自闭症谱系障碍（ASD）（n=46350）、注意力缺陷多动障碍（ADHD）（n=55374）和抑郁症（DEP）（n=688809）进行了跨性状荟萃分析。荟萃分析后，ADHD 的基因组位点数量从 14 个增加到 19 个，ASD 从 3 个增加到 10 个，DEP 从 45 个增加到 57 个，BD 从 8 个增加到 54 个，SCZ 从 64 个增加到 87 个。我们观察到不同疾病之间重叠基因的显著富集，并确定了一组跨疾病基因。共有 7 个基因与五种精神疾病中的四种相关，分别为 GABBR1、GLT8D1、HIST1H1B、HIST1H2BN、HIST1H4L、KCNB1 和 DCC。SORCS3 基因由于涉及研究的所有五种疾病而受到关注。相关性分析揭示了两个相关精神疾病的聚类，即 SCZ 和 BD，它们与其他三种疾病分开，形成另一个群体。我们的结果可能为五种精神疾病的遗传基础提供新的见解。
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