Ulusoy Ersin Kasım, Bolattürk Ömer Faruk, Göl Mehmet Fatih
Department of Neurology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Ann Indian Acad Neurol. 2020 May-Jun;23(3):275-279. doi: 10.4103/aian.AIAN_249_19. Epub 2020 Jun 10.
This study aimed to establish whether there is a relationship between the Monocyte to High-Density Lipoprotein Cholesterol (HDL-C) ratio (MHR) and severity of disease, and whether it can be used as a new marker for predicting disability in Multiple Sclerosis (MS), a chronic disease, which is usually contracted in early adolescence.
184 patient subjects who had been definitively diagnosed with MS, based on the McDonald criteria, and 105 healthy subjects with a similar age and gender profile were included in the study. The patients' Expanded Disability Status Scale (EDSS) scores, MS subtypes, length of time with the disease and demographics were captured. Blood samples were collected for hematologic and biochemical testing. The MHR values were calculated and statistically compared with those of the control group.
The average age of the MS patients was 38.3 ± 8.6 years and their average EDSS score was 2.5 [0-7.5]. The patient arm consisted of 118 (64.1%) females and 66 (35.9%) males. In the patients with MS, the MHR was 15.01 ± 0.63 compared to 9.61 ± 0.25 in the controls. This difference was statistically significant ( < 0.001). In the MS patients, the MHR cut-off value was 12.95 compared to controls, which was statistically significant ( < 0.001). Also, a statistically-significant (r: 0.297, < 0.001) positive correlation was found between the MHR and EDSS score.
The Monocyte to High-Density Lipoprotein Cholesterol ratio is associated with disease severity and disability in MS patients, and may be used as an independent marker for predicting disability. However, broader-scale studies are needed for more conclusive results.
本研究旨在确定单核细胞与高密度脂蛋白胆固醇（HDL-C）比值（MHR）与疾病严重程度之间是否存在关联，以及它是否可作为预测多发性硬化症（MS）残疾情况的新标志物。MS是一种通常在青春期早期发病的慢性疾病。
本研究纳入了184例根据麦克唐纳标准确诊为MS的患者以及105例年龄和性别分布相似的健康受试者。记录患者的扩展残疾状态量表（EDSS）评分、MS亚型、患病时长和人口统计学信息。采集血样进行血液学和生化检测。计算MHR值，并与对照组进行统计学比较。
MS患者的平均年龄为38.3±8.6岁，平均EDSS评分为2.5[0 - 7.5]。患者组中女性有118例（64.1%），男性有66例（35.9%）。MS患者的MHR为15.01±0.63，而对照组为9.61±0.25。这种差异具有统计学意义（<0.001）。与对照组相比，MS患者的MHR截断值为12.95，具有统计学意义（<0.001）。此外，还发现MHR与EDSS评分之间存在统计学显著的正相关（r：0.297，<0.001）。
单核细胞与高密度脂蛋白胆固醇比值与MS患者的疾病严重程度和残疾情况相关，可能作为预测残疾的独立标志物。然而，需要更广泛的研究以获得更确凿的结果。
