Zheng Wei, Jiang Miao-Ling, He Hong-Bo, Li Ri-Peng, Li Qi-Long, Zhang Chun-Ping, Zhou Su-Miao, Yan Su, Ning Yu-Ping, Huang Xiong
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, People's Republic of China.
The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Neuropsychiatr Dis Treat. 2020 Jun 22;16:1555-1560. doi: 10.2147/NDT.S256278. eCollection 2020.
Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of depression and in the antidepressant response. This study examined whether changes in serum BDNF levels are associated with the antidepressant effects of nonconvulsive electrotherapy (NET).
For BDNF analyses, serum samples were collected from 20 patients with treatment-refractory depression (TRD) and from 20 healthy controls. Serum samples were also collected from patients following a course of NET.
Although significantly lower baseline serum BDNF levels were observed in TRD patients than in healthy controls, no changes in serum BDNF levels were found in TRD patients after a course of NET compared to baseline. No significant association was found between serum BDNF levels and depression severity.
Serum BDNF levels appear to have no clinical utility in the prediction of the antidepressant effects of NET in patients with TRD. Future studies of higher quality and with larger sample sizes are needed to confirm these findings.
脑源性神经营养因子（BDNF）与抑郁症的病理生理学及抗抑郁反应有关。本研究探讨血清BDNF水平的变化是否与非惊厥性电疗法（NET）的抗抑郁作用相关。
为进行BDNF分析，从20例难治性抑郁症（TRD）患者和20名健康对照者中采集血清样本。还在接受一个疗程NET治疗后的患者中采集血清样本。
尽管观察到TRD患者的基线血清BDNF水平显著低于健康对照者，但与基线相比，TRD患者在接受一个疗程NET治疗后血清BDNF水平未发现变化。血清BDNF水平与抑郁严重程度之间未发现显著关联。
血清BDNF水平在预测TRD患者NET的抗抑郁作用方面似乎没有临床实用性。需要开展更高质量、更大样本量的未来研究来证实这些发现。
