Rozjabek Heather, Fastenau John, LaPrade Anne, Sternbach Nikoletta
Janssen Global Services, Raritan, NJ, USA.
Kantar, New York, NY, USA.
Diabetes Metab Syndr Obes. 2020 Jun 17;13:2049-2055. doi: 10.2147/DMSO.S245486. eCollection 2020.
While it is generally believed that people living with more severe obesity experience greater negative impacts on health-related quality of life (HRQoL), their experience may be impacted by other factors such as age, gender, and type 2 diabetes mellitus (T2DM).
The 36-Item Short Form Health Survey physical component score and mental component score, Work Productivity and Activity Impairment, and Patient Activation Measure data from the 2018 National Health and Wellness Survey were analyzed in adults by body mass index (BMI) categories (normal weight: ≥18.5-<25kg/m, overweight: ≥25-<30kg/m, class 1 obesity: ≥30-<35kg/m, class 2 obesity: ≥35-<40kg/m, class 3 obesity: ≥40kg/m, combined class 2/3 obesity: ≥35kg/m). Findings were further stratified across age groups (young: 18-35y, middle-aged: 36-64y, older: ≥65y), by gender, and by T2DM status.
Overall, as BMI increased people had greater negative effects on HRQoL, felt less involved with and in control of their healthcare, and had greater work productivity and activity impairments. The largest declines were generally observed between class 2 and 3 obesity categories. Young adults with obesity were more likely to feel less engaged with their health care than middle-aged/older adults with obesity. The effects of obesity on HRQoL and patient activation were generally consistent by gender. People with T2DM and obesity tended to have greater declines in physical functioning and more work and activity impairments than people with obesity without T2DM. The proportion of people trying to lose weight increased with increasing BMI category, and people with T2DM were less likely to exercise and more likely to diet than those without T2DM.
Increasing levels of obesity tended to have a greater negative impact on HRQoL, patient activation, work productivity, and weight loss behaviors, but some differences in effects by age, gender, and T2DM status were observed.
虽然人们普遍认为,患有更严重肥胖症的人对健康相关生活质量(HRQoL)的负面影响更大,但他们的体验可能会受到其他因素的影响,如年龄、性别和2型糖尿病(T2DM)。
对2018年国民健康与 Wellness 调查中的36项简短健康调查问卷的身体成分得分和心理成分得分、工作效率和活动障碍以及患者激活测量数据,按体重指数(BMI)类别(正常体重:≥18.5-<25kg/m²,超重:≥25-<30kg/m²,1级肥胖:≥30-<35kg/m²,2级肥胖:≥35-<40kg/m²,3级肥胖:≥40kg/m²,2/3级肥胖合并:≥35kg/m²)对成年人进行分析。研究结果按年龄组(年轻人:18-35岁,中年人:36-64岁,老年人:≥65岁)、性别和T2DM状态进一步分层。
总体而言,随着BMI的增加,人们对HRQoL的负面影响更大,感觉对自身医疗保健的参与度和掌控力更低,工作效率和活动障碍也更大。通常在2级和3级肥胖类别之间观察到最大降幅。肥胖的年轻人比肥胖的中年/老年人更有可能感觉对自身医疗保健的参与度较低。肥胖对HRQoL和患者激活的影响在性别上总体一致。患有T2DM和肥胖症的人在身体功能方面的下降往往比没有T2DM的肥胖症患者更大,工作和活动障碍也更多。试图减肥的人的比例随着BMI类别的增加而增加,与没有T2DM的人相比,患有T2DM的人锻炼的可能性更小,节食的可能性更大。
肥胖程度的增加往往对HRQoL、患者激活、工作效率和减肥行为产生更大的负面影响,但在年龄、性别和T2DM状态的影响方面存在一些差异。