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[前文缺失物质名称]的总黄酮可减轻小鼠的认知障碍。

Total flavonoids of alleviates cognitive impairment in mice.

作者信息

Zhang Lianzhu, Zhang Yang, Hou Yating, Li Haiyan, Li Chikun, Xin Jile, Zhou Nana, Li Qingjie, Song Yu, Zhang Zhengyao

机构信息

College of Fisheries and Life Science, Hainan Tropical Ocean University, Sanya, Hainan 572022, P.R. China.

Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130022, P.R. China.

出版信息

Biomed Rep. 2020 Aug;13(2):8. doi: 10.3892/br.2020.1315. Epub 2020 Jun 9.

DOI:10.3892/br.2020.1315
PMID:32607237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7323453/
Abstract

Cognitive impairment (CI) refers to dysfunctional cognition, which encompasses a spectrum of disorders, ranging from mild cognitive impairment to dementia. Any factor that results in cortical damage may cause CI. Total flavonoids of (TFSP), have shown promising antioxidant and protective effects in animal models. In the present study, mice were intraperitoneally treated with scopolamine, sodium nitrite or 45% ethanol to induce memory impairment, and the effects were assessed using a step-down test. After performing the behavioural test, hippocampal sections were collected for anatomical analysis, and the brain and serum levels of memory-related molecules were evaluated. The results showed that TFSP improved memory in a mouse model of CI significantly. Serum data were consistent with the behavioural results: TFSP increased blood acetylcholine levels through modulation of the acetylcholinesterase and choline acetyltransferase levels. It also ameliorated oxidative stress in neurons, increasing superoxide dismutase, glutathione peroxidase and inhibiting nitric oxide synthase levels in the brain. These results suggest that TFSP may exhibit potential as a clinical treatment for neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, and senile dementia.

摘要

认知障碍（CI）是指认知功能失调，其涵盖一系列疾病，从轻度认知障碍到痴呆症。任何导致皮质损伤的因素都可能引起CI。[具体植物名称]总黄酮（TFSP）在动物模型中已显示出有前景的抗氧化和保护作用。在本研究中，给小鼠腹腔注射东莨菪碱、亚硝酸钠或45%乙醇以诱导记忆障碍，并使用跳台试验评估其效果。进行行为测试后，收集海马切片进行解剖分析，并评估大脑和血清中与记忆相关分子的水平。结果表明，TFSP显著改善了CI小鼠模型的记忆。血清数据与行为结果一致：TFSP通过调节乙酰胆碱酯酶和胆碱乙酰转移酶水平来提高血液中乙酰胆碱水平。它还改善了神经元中的氧化应激，增加了超氧化物歧化酶、谷胱甘肽过氧化物酶，并抑制了大脑中一氧化氮合酶的水平。这些结果表明，TFSP可能具有作为包括帕金森病、阿尔茨海默病和老年痴呆症在内的神经退行性疾病临床治疗方法的潜力。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ac/7323453/715a7edd396c/br-13-02-01315-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ac/7323453/d24af32fb89c/br-13-02-01315-g09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ac/7323453/710215004eb6/br-13-02-01315-g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ac/7323453/21cb254943c0/br-13-02-01315-g11.jpg
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