穗花杉双黄酮保护海马神经元：抗炎、抗氧化和抗凋亡作用。

Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects.

作者信息

Zhang Zhen, Sun Tao, Niu Jian-Guo, He Zhen-Quan, Liu Yang, Wang Feng

机构信息

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China ; Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.

出版信息

Neural Regen Res. 2015 Jul;10(7):1125-33. doi: 10.4103/1673-5374.160109.

Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. We presumed that amentoflavone exerts a neuroprotective effect in epilepsy models. Prior to model establishment, mice were intragastrically administered 25 mg/kg amentoflavone for 3 consecutive days. Amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-κB activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons. Results suggested that amentoflavone protected hippocampal neurons in epilepsy mice via anti-inflammation, antioxidation, and antiapoptosis, and then effectively prevented the occurrence of seizures.

穗花杉双黄酮是一种具有多种生物学特性的天然双黄酮化合物，包括抗炎、抗氧化和神经保护作用。我们推测穗花杉双黄酮在癫痫模型中发挥神经保护作用。在建立模型之前，小鼠连续3天经胃给予25 mg/kg穗花杉双黄酮。穗花杉双黄酮在小鼠点燃模型中有效预防了毛果芸香碱诱导的癫痫，抑制了核因子-κB的激活和表达，抑制了海马神经元的过度放电，从而减少癫痫发作，缩短发作时间，并减少海马神经元的丢失和凋亡。结果表明，穗花杉双黄酮通过抗炎、抗氧化和抗凋亡作用保护癫痫小鼠的海马神经元，进而有效预防癫痫发作的发生。