Toyoda M, Arai S, Sakuragawa N, Hara T, Iio M
Department of Pediatric Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
No To Shinkei. 1988 Mar;40(3):267-72.
In order to investigate in vivo metabolism of pyruvate in the brain, positron emission tomography (PET) using pyruvate-1-11C were performed on two patients with mitochondrial encephalomyopathy, one patient with Leigh disease and one patient with epilepsy. PET images of epilepsy showed less RI uptakes in brain tissues than in skull muscles. And RI was cleared rapidly from the brain tissues. But PET images of mitochondrial encephalomyopathies showed increased RI uptakes and slow RI clearance in cerebral cortices, basal ganglia and thalamus. Also RI was cleared slowly or accumulated in ventricles. This suggested that pyruvate metabolism may be impaired with metabolical trapping of 11C by lactic acids, since it is said that 11C of pyruvate-1-11C is cleared rapidly from the normal brain tissues by decarboxylation of pyruvate. The usefulness of PET studies with pyruvate-1-11C are suggested for investigating pyruvate metabolism in brain tissues, and for diagnosing mitochondrial encephalomyopathy.
为了研究丙酮酸在大脑中的体内代谢情况，对两名线粒体脑肌病患者、一名 Leigh 病患者和一名癫痫患者进行了使用丙酮酸 -1-¹¹C 的正电子发射断层扫描（PET）检查。癫痫患者的 PET 图像显示，脑组织中的放射性摄取比颅骨肌肉中的少。并且放射性迅速从脑组织中清除。但线粒体脑肌病患者的 PET 图像显示，大脑皮质、基底神经节和丘脑的放射性摄取增加且放射性清除缓慢。此外，放射性在脑室中清除缓慢或积聚。这表明丙酮酸代谢可能因乳酸对¹¹C 的代谢捕获而受损，因为据说丙酮酸 -1-¹¹C 中的¹¹C 通过丙酮酸脱羧作用可从正常脑组织中迅速清除。使用丙酮酸 -1-¹¹C 进行 PET 研究对于研究脑组织中的丙酮酸代谢以及诊断线粒体脑肌病具有重要意义。
