Toyoda M, Sakuragawa N, Arai Y, Yoshikawa H, Sugai K, Arima M, Hara T, Iio M, Satoyoshi E
Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Tokyo, Japan.
Ann Nucl Med. 1989 Jul;3(2):103-9. doi: 10.1007/BF03164593.
Positron emission tomography (PET) using pyruvate-1-11C was carried out to investigate the in vivo metabolism of pyruvate in the brains of patients with mitochondrial encephalomyopathy and Leigh's disease. Two epileptic patients were studied as control subjects. Radioactivity was eliminated from the brain tissue of the epileptic patients soon after injection of pyruvate-1-11C. PET images of mitochondrial encephalomyopathy patients showed an increase in radioactivity in the cerebral cortex, basal ganglia and thalamus, with elimination of radioactivity being slower than that of epileptic patients. One patient with Leigh's disease showed similar PET images. PET using pyruvate-1-11C is useful for the evaluation of mitochondrial energy metabolism in the brain.
采用1-11C-丙酮酸的正电子发射断层扫描（PET）技术，对线粒体脑肌病和Leigh病患者大脑中丙酮酸的体内代谢情况进行了研究。选取两名癫痫患者作为对照对象。注射1-11C-丙酮酸后，癫痫患者脑组织中的放射性很快就消失了。线粒体脑肌病患者的PET图像显示，大脑皮质、基底神经节和丘脑的放射性增加，放射性的消除比癫痫患者慢。一名Leigh病患者的PET图像与之相似。采用1-11C-丙酮酸的PET技术有助于评估大脑中的线粒体能量代谢。
