Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh 700000, Viet Nam.
Faculty of Food Technology, Nha Trang University, 02 Nguyen Dinh Chieu, Nha Trang 650000, Viet Nam.
J Asian Nat Prod Res. 2021 Aug;23(8):754-763. doi: 10.1080/10286020.2020.1783658. Epub 2020 Jul 1.
Three new compounds (methyl-3,25-dihydroxycycloart-23-en-29-oate 3-sulfate (), methyl-3-hydroxy-25-methoxycycloart-23-en-29-oate 3-sulfate () and 3-hydroxy-25-methoxycycloart-23-ene 3-sulfate ()) and a known one (3-hydroxycycloart-24-en-23-one 3-sulfate ()) were isolated from Vietnamese red alga . All isolated compounds - showed potent inhibitory activity against yeast α-glucosidase with IC values of 16.62 ± 2.80, 36.34 ± 4.04, 30.19 ± 5.01 and 6.52 ± 0.17 µM, respectively. The docking data showed that the substitutions at C-3 and the differences in the side chain of cycloartane-skeleton could influence the interaction of molecule with enzyme, which was consistent with the experimental findings.[Formula: see text].
从越南红藻中分离得到三种新化合物（甲基-3,25-二羟基环阿尔廷-23-烯-29-酸 3-硫酸盐 (3-sulfate) (), 甲基-3-羟基-25-甲氧基环阿尔廷-23-烯-29-酸 3-硫酸盐 () 和 3-羟基-25-甲氧基环阿尔廷-23-烯 3-硫酸盐 ()）和一种已知化合物（3-羟基环阿尔廷-24-烯-23-酮 3-硫酸盐 ()）。所有分离得到的化合物 - 对酵母 α-葡萄糖苷酶表现出强烈的抑制活性，IC 值分别为 16.62 ± 2.80、36.34 ± 4.04、30.19 ± 5.01 和 6.52 ± 0.17 μM。对接数据表明，环阿尔廷骨架 C-3 上的取代和侧链的差异会影响分子与酶的相互作用，这与实验结果一致。
