A new feruloylfriedelinol from the stems of and its α-glucosidase inhibition.

Phytochemical investigation of the stems of led to the isolation of a new triterpene, 3---feruloylfriedelinol (), together with five known compounds, friedelin (), 3-friedelinol (), lupeol (), stigmasterol (), and 4-(1,5-dimethyl-3-oxo-4-hexenyl)benzoic acid (). Their structures were identified by intensive spectroscopic analysis including 1D and 2D nuclear magnetic resonance, infrared, and mass spectrometry. Compound showed significant α-glucosidase inhibitory activity (IC = 337.49 ± 0.59 µM) close to the standard, acarbose. Furthermore, the structure activity relationship of was analyzed by molecular docking studies. In addition, the molecular docking results showed that the interaction between and the active site occurred through hydrophobic forces and hydrogen bonds.