Multidisciplinary Research Unit of Pure and Applied Chemistry, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham, Thailand.
Diversity of Family Zingiberaceae and Vascular Plant for Its Applications Research Unit, Walai Rukhavej Botanical Research Institute, Mahasarakham University, Maha Sarakham, Thailand.
Nat Prod Res. 2024 Sep;38(18):3269-3274. doi: 10.1080/14786419.2023.2222218. Epub 2023 Jun 7.
Phytochemical investigation of the stems of led to the isolation of a new triterpene, 3---feruloylfriedelinol (), together with five known compounds, friedelin (), 3-friedelinol (), lupeol (), stigmasterol (), and 4-(1,5-dimethyl-3-oxo-4-hexenyl)benzoic acid (). Their structures were identified by intensive spectroscopic analysis including 1D and 2D nuclear magnetic resonance, infrared, and mass spectrometry. Compound showed significant α-glucosidase inhibitory activity (IC = 337.49 ± 0.59 µM) close to the standard, acarbose. Furthermore, the structure activity relationship of was analyzed by molecular docking studies. In addition, the molecular docking results showed that the interaction between and the active site occurred through hydrophobic forces and hydrogen bonds.
对 茎的植物化学研究导致分离出一种新的三萜，3---阿魏酰friedelinol ()，以及五种已知化合物，friedelin ()，3-friedelinol ()，羽扇豆醇 ()，豆甾醇 ()和 4-(1,5-二甲基-3-氧代-4-己烯基)苯甲酸 ()。通过包括 1D 和 2D 核磁共振、红外和质谱在内的综合光谱分析确定了它们的结构。化合物 表现出显著的α-葡萄糖苷酶抑制活性（IC = 337.49 ± 0.59 μM），接近标准阿卡波糖。此外，通过分子对接研究分析了 的构效关系。另外，分子对接结果表明， 与活性位点的相互作用是通过疏水作用力和氢键发生的。
