Benzofuran derivatives with nerve growth factor-potentiating activity from .

Three new benzofuran derivatives, namely ribisin E ribisin F along with ribisin G were isolated from the MeOH extract of the fruiting bodies of Their structures were elucidated based on the NMR analysis. Furthermore, the absolute configuration of ribisin E and ribisin G were deduced by the CD calculations, and the absolute configuration of ribisin F was determined by comparing its CD spectrum and specific rotation with the data of known analogues. All compounds exhibited the activity of promoting neurite outgrowth in nerve growth factor (NGF)-ediated PC 12 cell at concentrations ranging from 1 to 30 μM.