从川楝果实中分离得到的新型神经营养因子增强型柠檬苦素。
Novel NGF-potentiating limonoids from the fruits of Melia toosendan.
机构信息
Department of Pharmaceutical Science, Shanxi Medical University, No.56 Xinjian South Road, Taiyuan 030001, Shanxi, PR China.
出版信息
Fitoterapia. 2013 Oct;90:192-8. doi: 10.1016/j.fitote.2013.07.019. Epub 2013 Aug 3.
Four new limonoids (1-4), together with five known limonoids (5-9), were isolated from the fruits of Melia toosendan. Their structures were elucidated based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, IR, α). The isolated compounds were evaluated for their neurite outgrowth-promoting activities. Compounds 2 and 6 significantly enhanced NGF-mediated neurite outgrowth in PC12 cells at concentrations ranging from 0.1 to 50.0 μM.
从苦楝果实中分离得到了 4 个新的柠檬苦素（1-4）和 5 个已知的柠檬苦素（5-9）。基于广泛的光谱分析（1D 和 2D-NMR、HRESIMS、IR、α）阐明了它们的结构。对分离得到的化合物进行了促进神经突生长活性的评价。化合物 2 和 6 在 0.1-50.0 μM 浓度范围内显著增强了 NGF 介导的 PC12 细胞的神经突生长。
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