Department of Urology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Gynecol Endocrinol. 2020 Dec;36(12):1127-1130. doi: 10.1080/09513590.2020.1775195. Epub 2020 Jul 1.
36.9% of men worldwide use tobacco. Previous studies suggest a negative effect of cigarette smoking on semen quality, but the results are contradictory. We have studied the effects of smoking on the semen characteristics such as sperm concentration, semen volume, sperm motility, sperm vitality and sperm morphology in a large group of infertile men.
This retrospective study was conducted on a total of 5146 infertile men with at least one year of idiopathic infertility, who admitted to the Centre for Reproductive medicine (CRG) at the Brussels University Hospital, Belgium between 2010 and 2017. The smokers were classified as mild (1-10 cigarettes/d), moderate (11-20 cigarettes/d) or heavy smokers (> 20 cigarettes/d). Semen analysis was performed for all patients. Statistical analysis was performed using the R software package and t-test or Mann-Whitney U tests were used, group comparisons were performed using ANOVA, ANCOVA or Kruskal-Wallis tests as appropriate. A p-value <0.05 was considered as statistically significant.
Comparing the semen parameters in the two global groups showed that smoking had a significant decrease in semen volume (=0.04074) and sperm concentration (=0.029). ANOVA testing on the different smoking groups versus non-smoking group showed a significant decrease in sperm concentration (=0.0364). After adjusting for the confounders, age and testosterone, ANCOVA testing showed significant effect on the sperm concentration (=0.03871) in smokers versus non-smokers. No significant correlation was detected between the other semen characteristics.
We concluded that smoking had a significant and independent effect on the sperm concentration in a semen analysis. Other parameters, like semen volume, sperm motility, sperm vitality and sperm morphology were not influenced by smoking.
全球 36.9%的男性吸烟。先前的研究表明，吸烟会对精液质量产生负面影响，但结果存在矛盾。我们研究了吸烟对大量不育男性精液特征的影响，如精子浓度、精液量、精子活力和精子形态。
这项回顾性研究共纳入了 5146 名至少有一年特发性不育的不育男性，他们于 2010 年至 2017 年在比利时布鲁塞尔大学医院生殖医学中心（CRG）就诊。吸烟者分为轻度（1-10 支/天）、中度（11-20 支/天）或重度（>20 支/天）吸烟者。对所有患者进行精液分析。使用 R 软件包进行统计分析，使用 t 检验或曼-惠特尼 U 检验进行组间比较，使用方差分析、协方差分析或克鲁斯卡尔-沃利斯检验进行适当的组间比较。p 值<0.05 被认为具有统计学意义。
比较两组全球人群的精液参数显示，吸烟使精液量（=0.04074）和精子浓度（=0.029）显著降低。对不同吸烟组与非吸烟组进行方差分析显示，精子浓度显著降低（=0.0364）。调整混杂因素年龄和睾酮后，协方差分析显示，吸烟组与非吸烟组的精子浓度存在显著差异（=0.03871）。其他精液特征之间未检测到显著相关性。
我们得出结论，吸烟对精液分析中的精子浓度有显著的独立影响。其他参数，如精液量、精子活力、精子活力和精子形态不受吸烟影响。
