CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.
Chem Commun (Camb). 2020 Aug 7;56(61):8667-8670. doi: 10.1039/d0cc03082a. Epub 2020 Jul 1.
Four types of quadruplex supramolecules containing G-quadruplex (G4)-I-motif interfaces were assembled under slightly acidic conditions, which can interact with hemin to form I-motif-linked G4/hemin DNAzymes. Our data demonstrated that some I-motif-linked DNAzymes are highly acid-dependent due to the stabilization of hemiprotonated cytosine-cytosine (C˙CH) pairs for the G4 units.
四种含有 G-四链体（G4）-I 型基序界面的四联体超分子在微酸性条件下组装，可与血红素相互作用形成 I 型基序连接的 G4/血红素 DNA 酶。我们的数据表明，一些 I 型基序连接的 DNA 酶高度依赖于酸，这是由于 G4 单元中半质子化的胞嘧啶-胞嘧啶（C˙CH）对的稳定。
