Bryant H U, Yoburn B C, Inturrisi C E, Bernton E W, Holaday J W
Department of Medical Neuroscience, Walter Reed Army Institute of Research, Washington, DC 20307.
Eur J Pharmacol. 1988 Apr 27;149(1-2):165-9. doi: 10.1016/0014-2999(88)90057-x.
Morphine pellets produced atrophy of the spleen and thymus and affected mitogen-induced lymphocyte proliferation in mice as characterized by marked suppression of concanavalin A-induced blastogenesis at 48 h, and mild stimulation at 120 h. Morphine blood levels in these animals indicated that changes in the immunomodulatory effects of morphine over time were not related to dramatic shifts in circulating morphine. Enclosure of the pellet in nylon mesh did not alter blood levels or morphine-induced immunomodulation.
吗啡微丸导致小鼠脾脏和胸腺萎缩，并影响有丝分裂原诱导的淋巴细胞增殖，其特征为在48小时时显著抑制刀豆蛋白A诱导的细胞增殖，而在120小时时出现轻度刺激。这些动物的吗啡血药浓度表明，吗啡免疫调节作用随时间的变化与循环中吗啡的显著变化无关。将微丸包裹在尼龙网中并不会改变血药浓度或吗啡诱导的免疫调节作用。
