Lucivero G, Pierucci G, Bonomo L
Istituto di Medicina Clinica, University of Bari, Italy.
Eur Respir J. 1988 Apr;1(4):337-40.
We have examined the distribution of B and T lymphocytes, T-cells with helper/inducer (T4+) or suppressor/cytotoxic (T8+) phenotypes and a subset of cells with natural killer (NK) activity and positive for the Leu 7 (HNK-1) surface antigen in peripheral blood and in lymphocyte-rich pleural effusions of patients with tuberculosis or malignancies (mesothelioma and lung cancer with pleural metastasis). In individual patients, the percentages of T lymphocytes were uniformly higher in pleural effusions than in peripheral blood; however, lower percentages of B lymphocytes and cells positive for the Leu 7 antigen were present in pleural fluids. The analysis of T-cell subpopulations demonstrated a selective enrichment of T lymphocytes with helper/inducer phenotype in pleural effusions, while the percentages of T-cells with suppressor/cytotoxic phenotype were similar in pleural fluid and peripheral blood. These results indicate that in lymphocytic pleural effusions the main lymphoid cell population is represented by T lymphocytes with helper/inducer phenotype, regardless of whether the effusion is due to tuberculosis or malignancies such as mesothelioma or lung cancer.
我们检测了结核病或恶性肿瘤（间皮瘤和伴有胸膜转移的肺癌）患者外周血及富含淋巴细胞的胸腔积液中B淋巴细胞、具有辅助/诱导（T4+）或抑制/细胞毒性（T8+）表型的T细胞以及具有自然杀伤（NK）活性且Leu 7（HNK-1）表面抗原呈阳性的细胞亚群的分布情况。在个体患者中，胸腔积液中T淋巴细胞的百分比始终高于外周血；然而，胸腔积液中B淋巴细胞和Leu 7抗原阳性细胞的百分比更低。对T细胞亚群的分析表明，胸腔积液中具有辅助/诱导表型的T淋巴细胞有选择性富集，而具有抑制/细胞毒性表型的T细胞在胸腔积液和外周血中的百分比相似。这些结果表明，在淋巴细胞性胸腔积液中，主要的淋巴细胞群体是具有辅助/诱导表型的T淋巴细胞，无论积液是由结核病还是间皮瘤或肺癌等恶性肿瘤引起的。
