Kochman S, Bernard J, Lavaud F, Cazabat A, Dubois de Montreynaud J M
Eur J Respir Dis. 1984 Nov;65(8):586-91.
T-lymphocyte subpopulations in pleural fluid and in peripheral blood from 17 patients admitted for pleural effusion were identified by E-rosette formation and delineated by monoclonal antibodies OKT3 (peripheral T-cells), OKT4 (helper/inducer cells), and OKT8 (suppressor/cytotoxic cells). We studied 13 patients with specified pleural diseases (tuberculosis, malignancies, connective tissue diseases, congestive heart failure) and 4 patients with non-specified pleural diseases. Our findings showed that the percentage of T-cells increases in pleural fluid versus peripheral blood whatever the diagnosis is, and that these T-cells are predominantly helper/inducer cells. Moreover, a recently described T-lymphocyte subpopulation, which expresses neither T3 nor other monoclonal antibody-defined markers, seems to be concentrated in the pleural fluid, especially in tuberculosis and malignant effusions. Although T-lymphocyte delineation seems to fail to aid in etiological diagnosis of pleurisy, such determinations could provide informations about local pathogenic mechanisms.
通过E花环形成法鉴定了17例因胸腔积液入院患者胸腔积液和外周血中的T淋巴细胞亚群，并用单克隆抗体OKT3（外周T细胞）、OKT4（辅助/诱导细胞）和OKT8（抑制/细胞毒性细胞）进行了描述。我们研究了13例患有特定胸腔疾病（结核病、恶性肿瘤、结缔组织病、充血性心力衰竭）的患者和4例患有非特定胸腔疾病的患者。我们的研究结果表明，无论诊断如何，胸腔积液中T细胞的百分比相对于外周血均增加，并且这些T细胞主要是辅助/诱导细胞。此外，最近描述的一种既不表达T3也不表达其他单克隆抗体定义标志物的T淋巴细胞亚群似乎集中在胸腔积液中，尤其是在结核病和恶性胸腔积液中。虽然T淋巴细胞的描述似乎无助于胸膜炎的病因诊断，但此类测定可为局部致病机制提供信息。
