van Gelder T, van Schaik R H N
LUMC, afd. Klinische Farmacie & Toxicologie, Leiden.
Contact: T. van Gelder (
Ned Tijdschr Geneeskd. 2020 Jun 4;164:D4191.
With the exception of a few medical specialties, the implementation of pharmacogenetic tests in daily practice has thus far been limited. The Royal Dutch Pharmacists Association (KNMP) has developed pharmacogenetics-based therapeutic doserecommendations for 80 medicinal product combinations on the basis of a systematic literature review. Genotyping of patients can take place on a reactive or pre-emptive basis; the advantage of pre-emptive genotyping is that it provides genetic information the moment a medicinal product is prescribed. Clinical decision support software is crucial to implement pharmacogenetics into daily practice.
除了少数医学专科外，药物遗传学检测在日常实践中的应用迄今为止一直有限。荷兰皇家药剂师协会（KNMP）在系统文献综述的基础上，为80种药物组合制定了基于药物遗传学的治疗剂量建议。患者的基因分型可以在反应性或预防性基础上进行；预防性基因分型的优势在于，在开具药品处方时就能提供基因信息。临床决策支持软件对于将药物遗传学应用于日常实践至关重要。
